Do gene-environment interactions influence fasting plasma lipids? A study of twins

European Journal of Clinical Investigation
J R GreenfieldL V Campbell

Abstract

The aims of this study were to determine the influence of smoking, alcohol consumption, physical activity and hormone replacement therapy (HRT) on lipids, independently of genetic factors, and to detect whether gene-environment interactions influence these associations. Fasting plasma total cholesterol, LDL cholesterol, HDL cholesterol, triglycerides, apolipoproteins AI and B and lipoprotein(a) were measured in 685 female twins (96 monozygotic, 230 dizygotic pairs and 33 singletons). Smokers had higher triglyceride and lower HDL cholesterol levels than never-smokers (P < 0.001). After controlling for genetic influences, smoking accounted for 0.35 mmol L(-1) and 0.22 mmol L(-1) differences in triglyceride and HDL cholesterol levels, respectively (P < 0.005), remaining significant after excluding alcohol-discordant twin pairs. In a gene-environment interaction analysis, the association between smoking and triglycerides was exaggerated in subjects at high genetic risk of hypertriglyceridaemia (interaction P=0.04). All levels of alcohol consumption were associated with higher HDL cholesterol levels than abstinence, but only moderate alcohol consumers had lower LDL cholesterol and triglyceride levels. In monozygotic twins concordant...Continue Reading

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Citations

Oct 2, 2007·Twin Research and Human Genetics : the Official Journal of the International Society for Twin Studies·Ellen L GoodeMariza de Andrade
Jan 20, 2006·Obesity Research·Katherine Samaras, Lesley Campbell
Dec 13, 2006·The Journal of Heredity·Dennis F LawlerKarl G Lark

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