Do human RNA helicases have a role in cancer?

Biochimica Et Biophysica Acta
Mohamed Abdelhaleem

Abstract

Human RNA helicases (HRH) represent a large family of enzymes that play important roles in RNA processing. The biochemical characteristics and biological functions of the majority of HRH are still to be determined. However, there are examples of dysregulation of HRH expression in various types of cancer. In addition, some HRH have been shown to be involved in the regulation of, or the molecular interaction with, molecules implicated in cancer. Other helicases take part in fusion transcripts resulting from cancer-associated chromosomal translocation. These findings raise the question of whether HRH can contribute to cancer development/progression. In this review, I summarize the cancer-related features of HRH.

References

Feb 1, 1992·Molecular Microbiology·S R Schmid, P Linder
Jun 16, 1989·Cell·M ScheffnerH Stahl
Jan 12, 1989·Nature·P LinderP P Slonimski
Aug 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·R IggoN K Spurr
Jul 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·J EriksonC M Croce
Sep 14, 1995·Biochemical and Biophysical Research Communications·H SandhuU A Heinlein
Aug 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·R Godbout, J Squire
Jan 1, 1994·Immunogenetics·C De SmetT Boon
May 1, 1993·Japanese Journal of Cancer Research : Gann·S IidaR Ueda
Jan 1, 1993·Life Sciences·L Lemaire, U A Heinlein
Mar 1, 1993·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·L BalvayM Y Fiszman
Oct 1, 1996·Nucleic Acids Research·G M LammA I Lamond
Apr 25, 1997·The Journal of Biological Chemistry·S Zhang, F Grosse
Mar 1, 1996·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·L RichterM I Kuroda
May 2, 1997·International Journal of Cancer. Journal International Du Cancer·J EberleC E Orfanos
Mar 28, 1998·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·R E GeorgeJ Lunec
Aug 6, 1998·Cytogenetics and Cell Genetics·P S WhiteG M Brodeur
Aug 8, 1998·The Journal of Biological Chemistry·R GodboutW Bie
Sep 25, 1998·Critical Reviews in Biochemistry and Molecular Biology·A LükingU Schmidt
Nov 13, 1998·Proceedings of the National Academy of Sciences of the United States of America·C G LeeJ Hurwitz
Dec 29, 1998·The Journal of Biological Chemistry·P S SubramaniamH M Johnson
Jan 20, 1999·Proceedings of the National Academy of Sciences of the United States of America·J LiF Wong-Staal
Feb 5, 1999·Proceedings of the Society for Experimental Biology and Medicine·Z H Jiang, J Y Wu
Apr 17, 1999·Molecular and Cellular Biology·H TangF Wong-Staal
Apr 27, 1999·The International Journal of Biochemistry & Cell Biology·A De Benedetti, A L Harris
Apr 27, 1999·The International Journal of Biochemistry & Cell Biology·A W van der Velden, A A Thomas
May 14, 1999·Trends in Biochemical Sciences·J de la CruzP Linder

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Citations

May 12, 2005·Clinical Biochemistry·Mohamed Abdelhaleem
Jan 7, 2006·Nucleic Acids Research·Heike Uhlmann-SchifflerHans Stahl
Nov 30, 2010·Nucleic Acids Research·Anja JankowskyEckhard Jankowsky
Jan 24, 2009·Journal of Experimental & Clinical Cancer Research : CR·Chunling HuangZhongying Zhang
Oct 14, 2010·PloS One·Patrick SchützHerwig Schüler
Apr 9, 2013·Gene·Mohammed TariqueRenu Tuteja
May 11, 2005·Kidney International·Iñigo SantamaríaJorge B Cannata-Andía
Aug 23, 2011·Journal of Proteomics·Ashraf G MadianFred E Regnier
Sep 4, 2010·Trends in Biochemical Sciences·Eckhard Jankowsky
May 12, 2010·Current Opinion in Structural Biology·Margaret E Fairman-WilliamsEckhard Jankowsky
Jan 24, 2007·Experimental and Molecular Pathology·Zaman AlliMohamed Abdelhaleem
Dec 19, 2006·Experimental and Molecular Pathology·Yong ChenMohamed Abdelhaleem
Mar 19, 2015·Scientific Reports·Huayue LinZhong-Ying Zhang
Sep 29, 2006·Journal of Cellular Biochemistry·Chetan DhamneGary A Clawson
Mar 24, 2007·Microbiology and Immunology·Yuji SundenHirofumi Sawa
May 10, 2013·Wiley Interdisciplinary Reviews. RNA·Francis Robert, Jerry Pelletier
Feb 7, 2008·American Journal of Human Genetics·Sharon A SavageBlanche P Alter
Sep 9, 2006·Experimental and Molecular Pathology·Zaman AlliMohamed Abdelhaleem
Sep 27, 2005·Experimental and Molecular Pathology·Zaman AlliMohamed Abdelhaleem
Jul 1, 2015·Brain : a Journal of Neurology·Jinlong YinJong Heon Kim
Jan 30, 2013·Biochimica Et Biophysica Acta·Olga Rodríguez-GalánJesús de la Cruz
Jan 29, 2013·RNA Biology·Frances V Fuller-Pace
Apr 10, 2013·Oral Oncology·Tejas M ShahChaitanya G Joshi
Feb 2, 2010·Biochemical and Biophysical Research Communications·Hidenori TaniNaohiro Noda
Mar 13, 2012·Annual Review of Biophysics·Arnon HennEnrique M De La Cruz
Feb 9, 2012·Journal of Proteome Research·Stephanie M PützAlbert Sickmann
Aug 23, 2017·British Journal of Cancer·Shingo ItoSumiko Watanabe
Feb 25, 2011·Future Oncology·Frances V Fuller-Pace, Hayley C Moore
Jul 17, 2014·The Journal of Clinical Endocrinology and Metabolism·Gisella FiglioliFederica Gemignani
Jul 23, 2011·Nature Reviews. Molecular Cell Biology·Patrick Linder, Eckhard Jankowsky
Apr 13, 2012·Cancer Science·Minoru KatoHideki Wanibuchi
Feb 18, 2016·Oncotarget·Marco FidaleoMaria Paola Paronetto

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