PMID: 2111865Jan 1, 1990Paper

Do imipramine and dihydroergosine possess two components--one stimulating 5-HT1 and the other inhibiting 5-HT2 receptors?

Life Sciences
D Pericić, D Muck-Seler

Abstract

The mechanisms by which imipramine and dihydroergosine stimulate the 5-HT syndrome in rats and inhibit the head-twitch response in rats and mice were studied. Imipramine- and dihydroergosine-induced stimulation of the 5-HT syndrome was inhibited stereoselectively by propranolol, a high affinity ligand for 5-HT1 receptor sites, but not by ritanserin, a specific 5-HT2 receptor antagonist. (-)-Propranolol potentiated the inhibitory effect of imipramine, but not of dihydroergosine on the head-twitch response, while ritanserin was without effect. Neither imipramine nor dihydroergosine were able to stimulate the 5-HT syndrome in the animals pretreated with p-chlorophenylalanine. As expected, 8-OH-DPAT, a selective 5-HT1A receptor agonist, stimulated, and 5-HT1B agonists CGS 12066B and 1-(trifluoromethylphenyl)piperazine (TFMPP) failed to stimulate the 5-HT syndrome induced in rats by pargyline and 5-HTP administration. A higher dose of ritanserin inhibited the syndrome. While 8-OH-DPAT alone produced all behavioral components of the 5-HT syndrome, dihydroergosine or imipramine alone even at very high doses never produced tremor or a more intensive forepaw padding as seen when these drugs were given in combination with pargyline and 5...Continue Reading

References

Feb 14, 1989·European Journal of Pharmacology·J Arnt, J Hyttel
May 1, 1988·Journal of Neurochemistry·K Herrick-Davis, M Titeler
Apr 7, 1987·European Journal of Pharmacology·R F NealeM Williams
Jan 1, 1987·Journal of Medicinal Chemistry·R A Glennon
Jan 1, 1987·European Journal of Drug Metabolism and Pharmacokinetics·P CvelbarM Zorz
May 7, 1987·European Journal of Pharmacology·D Pericić, H Manev
Dec 1, 1984·Neuropharmacology·A R Green
May 20, 1983·European Journal of Pharmacology·D N Middlemiss, J R Fozard
Jan 1, 1983·European Journal of Drug Metabolism and Pharmacokinetics·A MrharA Lenardic

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Citations

Jan 1, 1993·Journal of Neural Transmission. General Section·D Muck-Seler, D Pericić
Oct 22, 1991·European Journal of Pharmacology·F BorsiniT Mennini
Jan 1, 1993·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·L Smejkal-JagarD Pericic
Feb 1, 1995·Immunopharmacology and Immunotoxicology·L Smejkal-Jagar, M Boranić
Dec 4, 2003·Journal of Pharmacological Sciences·Yoshihisa KitamuraYoshiro Tanizaki

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