Do immune checkpoint inhibitors perform identically in patients with weight extremes?

Immunotherapy
Elie El RassyCaroline Robert

Abstract

The interaction between the two recent hallmarks of carcinogenesis, the immune system and energetic metabolism, has not been well investigated. The limited literature available on this topic describes a correlation between the efficacy and safety of immune checkpoint inhibitors with body mass index. A key knowledge gap is the understanding of this correlation as outcomes are strongly affected highlighting the need to prospective studies in this regard. This paper evaluates the rationale to these correlations at weight extremes and suggests the evaluation patient's weights and associated inflammatory profile before the initiation of immune checkpoint inhibition in cancer patients.

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Citations

Sep 2, 2020·Expert Review of Anticancer Therapy·Friedlaender Alex, Addeo Alfredo
Oct 19, 2019·Oncology Nursing Forum·Diane Von AhMary E Cooley
Jun 25, 2020·International Journal of Molecular Sciences·Gaia GiannoneGiorgio Valabrega
Sep 2, 2020·International Journal of Molecular Sciences·Yolla HaibeAli Shamseddine
Mar 7, 2021·International Journal of Molecular Sciences·Rola El SayedAli Shamseddine
Apr 4, 2021·International Journal of Molecular Sciences·Alice IndiniFrancesco Grossi

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