Do laboratory challenge tests for occupational asthma represent what happens in the workplace?

The European Respiratory Journal
P S BurgeGareth I Walters

Abstract

Specific inhalation challenge (SIC) is the diagnostic reference standard for occupational asthma; however, a positive test cannot be considered truly significant unless it can be reproduced by usual work exposures. We have compared the timing and responses during SIC in hospital to Oasys analysis of serial peak expiratory flow (PEF) during usual work exposures.All workers with a positive SIC to occupational agents between 2006 and 2015 were asked to measure PEF every 2 h from waking to sleeping for 4 weeks during usual occupational exposures. Responses were compared between the laboratory challenge and the real-world exposures at work.All 53 workers with positive SIC were included. 49 out of 53 had records suitable for Oasys analysis, 14 required more than one attempt and all confirmed occupational work-related changes in PEF. Immediate SIC reactors and deterioration within the first 2 h of starting work were significantly correlated with early recovery, and late SIC reactors and a delayed start to workplace deterioration were significantly correlated with delayed recovery. Dual SIC reactions had features of immediate or late SIC reactions at work rather than dual reactions.The concordance of timings of reactions during SIC and...Continue Reading

References

May 1, 1979·Clinical Allergy·A J TaylorJ Pepys
Oct 1, 1983·Thorax·K YanA J Woolcock
Nov 1, 1981·The Journal of Allergy and Clinical Immunology·F E HargreaveJ Dolovich
Apr 1, 1994·The European Respiratory Journal·S C StentonD J Hendrick
Feb 14, 2007·Chest·Jeremy BeachBrian H Rowe
Feb 5, 2010·Respiratory Medicine·Vicky C MooreP Sherwood Burge
Mar 2, 2012·The European Respiratory Journal·X BaurUNKNOWN ERS Task Force on the Management of Work-related Asthma
Jul 11, 2012·Occupational Medicine·V C MooreP S Burge
Mar 8, 2014·The European Respiratory Journal·Olivier VandenplasUNKNOWN ERS Task Force on Specific Inhalation Challenges with Occupational Agents
Jan 23, 2015·Occupational and Environmental Medicine·G I WaltersP S Burge
Jun 27, 2015·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·L-P BouletD W Cockcroft
Mar 9, 2017·Occupational and Environmental Medicine·Chunshao HuXavier Munoz

❮ Previous
Next ❯

Citations

Jul 24, 2020·Occupational and Environmental Medicine·Vicky C MooreP Sherwood Burge
Sep 15, 2020·Allergy, Asthma, and Clinical Immunology : Official Journal of the Canadian Society of Allergy and Clinical Immunology·Madison MacKinnonM Diane Lougheed
Mar 14, 2019·Arhiv za higijenu rada i toksikologiju·Dina Skroza, Jelena Macan

❮ Previous
Next ❯

Related Concepts

Related Feeds

Asthma

This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.