Do long-lived mutant and calorie-restricted mice share common anti-aging mechanisms?--a pathological point of view.

Age
Yuji IkenoGene B Hubbard

Abstract

Rodent models are an invaluable resource for studying the mechanism of mammalian aging. In recent years, the availability of transgenic and knockout mouse models has facilitated the study of potential mechanisms of aging. Since 1996, aging studies with several long-lived mutant mice have been conducted. Studies with the long-lived mutant mice, Ames and Snell dwarf, and growth hormone receptor/binding protein knockout mice, are currently providing important clues regarding the role of the growth hormone/insulin like growth factor-1 axis in the aging process. Interestingly, these studies demonstrate that these long-lived mutant mice have physiological characteristics that are similar to the effects of calorie restriction, which has been the most effective experimental manipulation capable of extending lifespan in various species. However, a question remains to be answered: do these long-lived mutant and calorie-restricted mice extend their lifespan through a common underlying mechanism?

References

Jul 1, 1991·Acta Endocrinologica·A I EsquifinoA Bartke
Mar 1, 1988·Journal of Gerontology·R WeindruchR L Walford
Nov 1, 1985·Journal of Gerontology·H MaedaB P Yu
Jan 1, 1972·Pathologia et microbiologia·R Silberberg
Aug 1, 1965·General and Comparative Endocrinology·A Bartke
Jul 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·E J MasoroH A Bertrand
Nov 7, 1996·Nature·H M Brown-BorgA Bartke
Dec 16, 1997·Proceedings of the National Academy of Sciences of the United States of America·Y ZhouJ J Kopchick
Nov 14, 1998·Developmental Immunology·V De Mello-CoelhoM Dardenne
Mar 6, 1999·Endocrinology·V ChandrashekarJ J Kopchick
Apr 15, 1999·Journal of the National Cancer Institute·K D BurroughsJ A Taylor
Jun 6, 2000·Results and Problems in Cell Differentiation·A Bartke
Jun 30, 2000·Endocrinology·K T CoschiganoJ J Kopchick
Sep 21, 2000·Journal of the National Cancer Institute·H Yu, T Rohan
May 24, 2001·Proceedings of the National Academy of Sciences of the United States of America·K FlurkeyD E Harrison
Aug 7, 2001·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·A BartkeS Hauck
Oct 13, 2001·Trends in Molecular Medicine·S A Bustin, P J Jenkins
Nov 24, 2001·Mechanisms of Ageing and Development·Kevin FlurkeyDavid E Harrison
Nov 24, 2001·Nature·A BartkeG S Roth
Oct 31, 2002·Molecular Endocrinology·Richard A MillerAndrzej Bartke
Mar 29, 2003·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Yuji IkenoAndrzej Bartke
Mar 25, 2004·Physiological Genomics·Tomoshi TsuchiyaStephen R Spindler
Jul 3, 2004·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Darlene E BerrymanJohn J Kopchick
Sep 4, 2004·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Michal M MasternakAndrzej Bartke
Feb 9, 2005·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Maggie VergaraRichard A Miller
Jan 21, 2006·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Yuji IkenoJames F Nelson
Sep 15, 1929·Proceedings of the National Academy of Sciences of the United States of America·G D Snell
Jan 1, 2000·Journal of the American Aging Association·J A MattisonA Bartke

❮ Previous
Next ❯

Citations

Apr 5, 2011·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Kathy Ruth MagnussonPeter R Patrylo
Mar 6, 2009·Current Opinion in Gastroenterology·Luigi Fontana
Dec 1, 2010·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Colin Selman, Dominic J Withers
Sep 26, 2013·The Journal of Clinical Investigation·Arlan Richardson
Aug 24, 2013·Pathobiology of Aging & Age Related Diseases·Warren LadigesPiper M Treuting
Mar 31, 2015·Cell·Luigi Fontana, Linda Partridge
Apr 15, 2009·Biochimica Et Biophysica Acta·Luigi Fontana
Apr 8, 2014·Free Radical Biology & Medicine·Yael H Edrey, Adam B Salmon
Oct 25, 2017·Current Diabetes Reports·Saeid GolbidiIsmail Laher

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Proceedings of the National Academy of Sciences of the United States of America
K FlurkeyD E Harrison
The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
Maggie VergaraRichard A Miller
Proceedings of the National Academy of Sciences of the United States of America
Michael S BonkowskiAndrzej Bartke
© 2022 Meta ULC. All rights reserved