Do mice bred selectively for high locomotor activity have a greater reliance on lipids to power submaximal aerobic exercise?

American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
Nicole M TemplemanG B McClelland

Abstract

Patterns of fuel use during locomotion are determined by exercise intensity and duration, and are remarkably similar across many mammalian taxa. However, as lipids have a high yield of ATP per mole and are stored in large quantities, their use should be favored in endurance-adapted animals. To examine the capacity for alteration or differential regulation of fuel-use patterns, we studied two lines of mice that had been selectively bred for high voluntary wheel running (HR), including one characterized by small hindlimb muscles (HR(mini)) and one without this phenotype (HR(normal)), as well as a nonselected control line. We evaluated: 1) maximal aerobic capacity (Vo(2 max)); 2) whole body fuel use during exercise by indirect calorimetry; 3) cardiac properties; and 4) many factors involved in regulating lipid use. HR mice achieved an increased Vo(2 max) compared with control mice, potentially in part due to HR cardiac capacities for metabolic fuel oxidation and the larger relative heart size of HR(mini) mice. HR mice also exhibited enhanced whole body lipid oxidation rates at 66% Vo(2 max), but HR(mini), HR(normal), and control mice did not differ in the proportional mix of fuels sustaining exercise (% total Vo(2)). However, HR(m...Continue Reading

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Citations

Feb 21, 2013·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Bernard W M WoneJack P Hayes
Jan 31, 2013·Physiological Genomics·Jatin G BurnistonYi-Wen Chen
Dec 12, 2012·Current Biology : CB·Marie-Pierre SchippersGrant B McClelland
Jan 13, 2017·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Daphne S LauGrant B McClelland
Oct 10, 2013·Evolution; International Journal of Organic Evolution·Zachary A ChevironJay F Storz
Mar 18, 2021·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Sulayman A LyonsGrant B McClelland

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