Do microsatellites reflect genome-wide genetic diversity in natural populations? A comment on Väli et al. (2008)

Molecular Ecology
Marcus LjungqvistBengt Hansson

Abstract

A recent study by Väli et al. (2008) highlights that microsatellites will often provide a poor prediction of the genome-wide nucleotide diversity of wild populations, but does not fully explain why. To clarify and stress the importance of identity disequilibrium and marker variability for correlations between multilocus heterozygosity and genome-wide genetic variability, we performed a simple simulation with different types of markers, corresponding to microsatellites and SNPs, in populations with different inbreeding history. The importance of identity disequilibrium was apparent for both markers and there was a clear impact of marker variability.

References

Nov 1, 1969·Genetics·B S Weir, C C Cockerham
Jan 1, 1995·Annual Review of Genetics·R Frankham
Jul 28, 2001·Evolution; International Journal of Organic Evolution·D H Reed, R Frankham
Nov 28, 2002·Molecular Ecology·Bengt Hansson, Lars Westerberg
Feb 20, 2003·Proceedings. Biological Sciences·Carles VilàHans Ellegren
Jul 3, 2003·Evolution; International Journal of Organic Evolution·D W Coltman, J Slate
May 22, 2004·Nature Reviews. Genetics·Hans Ellegren
Jun 29, 2005·Journal of Molecular Evolution·Fabio PardiJohn C Whittaker
Oct 28, 2005·Genome Research·Rasmus NielsenCarlos Bustamante
Nov 16, 2005·Annual Review of Genetics·Rasmus Nielsen
May 17, 2006·Trends in Ecology & Evolution·Josephine Pemberton
Dec 7, 2006·Biology Letters·Olof LibergStaffan Bensch
Apr 7, 2007·Science·Nathan B SutterElaine A Ostrander
Mar 14, 2008·Nature·Hans Ellegren, Ben C Sheldon
May 31, 2008·Molecular Ecology·Henry M WoodRoger K Butlin
Sep 10, 2008·Genetica·Jon SlateJosephine M Pemberton

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Citations

May 21, 2014·The Journal of Heredity·Kevin E ColsonKris J Hundertmark
May 14, 2011·Molecular Ecology Resources·E GuichouxR J Petit
Jan 30, 2013·Molecular Ecology Resources·Jacquelin DeFaveriJuha Merilä
Mar 20, 2014·Conservation Biology : the Journal of the Society for Conservation Biology·Bradley CainPhillip C Watts
Dec 30, 2014·Ecology and Evolution·Alexander I Putman, Ignazio Carbone
Nov 19, 2013·PLoS Pathogens·Daniel J P EngelmoerDaniel E Rozen
Sep 18, 2010·Nature Reviews. Genetics·Fred W AllendorfGordon Luikart
Oct 26, 2011·Evolution; International Journal of Organic Evolution·Juanita Olano-MarinBart Kempenaers
Jul 3, 2019·Communications Biology·Tomoko HamabataTakashi Makino
Jan 12, 2020·Communications Biology·Tomoko HamabataTakashi Makino

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