Do MRI and mammography reliably identify candidates for breast conservation after neoadjuvant chemotherapy?

Annals of Surgical Oncology
Maxine S JochelsonM Morrow

Abstract

Neoadjuvant chemotherapy (NAC) may allow breast-conserving therapy (BCT) in patients who require mastectomy at presentation. Breast MRI is more accurate than mammography in assessing treatment response, but combined test reliability in identifying BCT candidates after NAC is not well described. We evaluated whether post-NAC breast MRI alone and with mammography accurately identifies BCT candidates. In this retrospective study of 111 consecutive breast cancer patients receiving NAC, all had pre- and postchemotherapy MRI, followed by surgery. Posttreatment MRI and mammography results were correlated with surgical outcomes and pathologic response. Fifty-one of 111 (46 %) patients presented with multicentric or inflammatory breast cancer and were not BCT candidates. The remaining 60 (54 %) were considered BCT candidates after downstaging (mean age: 47 years). All 60 had at least a partial response to NAC and were suitable for BCT on MRI after NAC. Forty-five of 60 (75 %) underwent lumpectomy; 15 of 60 (25 %) chose mastectomy. Forty-one of 45 (91 %) of lumpectomies were successful; 4 of 45 (9 %) required mastectomy. Twelve of 15 (80 %) patients choosing mastectomy could have undergone BCT based on pathology; 3 of 15 (20 %) did requi...Continue Reading

References

Jul 1, 1997·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·B FisherN V Dimitrov
Nov 16, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J A van der HageL Duchateau
Oct 16, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Harry D BearUNKNOWN National Surgical Adjuvant Breast and Bowel Project Protocol B-27
Oct 24, 2003·AJR. American Journal of Roentgenology·Eric L RosenMark W Dewhirst
Feb 3, 2005·Journal of the National Cancer Institute·Davide MauriJohn P A Ioannidis
May 21, 2005·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·T JuliusL W Turnbull
Mar 13, 2010·Annals of Surgery·Marieke E StraverKenneth G A Gilhuijs
May 25, 2012·Radiology·Nola M HyltonUNKNOWN ACRIN 6657 Trial Team and I-SPY 1 TRIAL Investigators
Jul 25, 2014·Annals of Surgical Oncology·Anna WeissSarah L Blair
Aug 26, 2014·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·A CharehbiliJ R Kroep

❮ Previous
Next ❯

Citations

Jun 16, 2017·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Ingeborg J H VriensUNKNOWN National Breast Cancer Organization of the Netherlands – Breast Cancer Audit Scientific Committee (NBCA)
May 8, 2019·AJR. American Journal of Roentgenology·Gary A Ulaner
Oct 16, 2018·Breast Care·Octavi CordobaCarmen Reyero-Fernández
Jan 14, 2021·AJR. American Journal of Roentgenology·Donna A EcksteinAmie Y Lee
Dec 20, 2020·American Journal of Surgery·Jessica L Thompson, G Paul Wright

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Ductal

Ductal carcinoma is a malignant neoplasm involving the ductal systems of any of a number of organs, such as the mammary glands, pancreas, prostate or lacrimal gland. Discover the latest research on ductal carcinoma here.

Carcinoma, Lobular

Lobular carcinoma is an invasive type of breast cancer in which lobules, areas of the breast that produce milk, undergo malignant transformation. Here is the latest research.