Do multiple data sets provide support for a bipolar illness susceptibility locus on chromosome 18?

Genetic Epidemiology
M J DalyL Kruglyak

Abstract

We carried out nonparametric linkage (NPL) analysis of the five chromosome 18 data sets for bipolar illness, as well as of the combined data set. Prior to analysis, we constructed a common genetic map and computed separate marker allele frequencies for each data set. We also attempted to create two consistent diagnostic categories, Narrow (bipolar I, BPI, only) and Broad. The results of the analysis of the combined data set provided stronger evidence of linkage under the Broad category, but at a level of significance that would be expected to occur by chance 4-5 times in a whole-genome scan. When the data sets were analyzed individually, the NIMH data set showed suggestive evidence of linkage (p = 0.0007). The other four data sets, considered together or separately, failed to support this finding, showing only slightly elevated allele sharing among affecteds at a level that would not be unexpected in an unlinked chromosomal region.

References

Jun 21, 1994·Proceedings of the National Academy of Sciences of the United States of America·W H BerrettiniE S Gershon

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Citations

Aug 12, 2006·Journal of Computational Biology : a Journal of Computational Molecular Cell Biology·Angela P PressonJeanette C Papp
Mar 5, 2002·Genome Research·Daniel E WeeksMichael B Gorin
Jul 14, 2001·The British Journal of Psychiatry. Supplement·Y SunR H Yolken
Dec 20, 2000·American Journal of Medical Genetics·M Baron

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