PMID: 11926005Apr 3, 2002Paper

Do mutations in Plasmodium falciparum dihydropteroate synthase and dihydrofolate reductase confer resistance to sulfadoxine-pyrimethamine in Iran?

Transactions of the Royal Society of Tropical Medicine and Hygiene
Abbas-Ali EskandarianFereidoun Mahboudi

Abstract

The key codons of dihydropteroate synthase (dhps) and dihydrofolate reductase (dhfr) genes implicated in sulfadoxine-pyrimethamine (SP) resistance were determined by allele-specific polymerase chain reaction in Plasmodium falciparum isolates collected in 1999 from 35 Iranian patients treated with SP. Seven isolates had Glu-540 dhps allele but 5 of these isolates were characterized to possess wild-type dhfr alleles. Seven additional isolates were polyclonal with mixed Lys- and Glu-540. The key dhfr mutation associated with pyrimethamine resistance, Asn-108, was found in 4 isolates. In one patient the presence of Lys- and Glu-540 in dhps and Asn-108 and Arg-59 in dhfr was associated with treatment failure. However, more studies are needed to determine whether clinical response to SP and mutations in these genes are correlated in Iran.

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Citations

Oct 7, 2006·Parasitology Research·Aliehsan HeidariHossein Keshavarz
Oct 20, 2005·The Journal of Infectious Diseases·Mahamadou A TheraChristopher V Plowe
Apr 28, 2006·The Journal of Antimicrobial Chemotherapy·Michelle L Gatton, Qin Cheng
Jan 11, 2007·Antimicrobial Agents and Chemotherapy·Toshihiro MitaTakatoshi Kobayakawa
May 25, 2004·Antimicrobial Agents and Chemotherapy·Michelle L GattonQin Cheng
Jan 16, 2007·Clinical Microbiology Reviews·David J Conway
Jan 17, 2004·Clinical Microbiology Reviews·Ambrose O TalisunaUmberto D'Alessandro
Jun 14, 2003·Annals of Tropical Medicine and Parasitology·S JafariR Durand
Sep 28, 2005·Tropical Medicine & International Health : TM & IH·Sedigheh ZakeriAnders Björkman
Nov 17, 2007·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Damaris S DiazTodd W Shearer

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