Do nasal ciliary changes reflect bronchial changes? An ultrastructural study

The American Review of Respiratory Disease
F VerraE Escudier

Abstract

Ciliary dyskinesia is characterized by recurrent respiratory tract infections secondary to abnormal ciliary structure and function. The diagnosis of ciliary dyskinesia is based on the detection of axonemal ultrastructural abnormalities (AUA) is respiratory mucosa samples. In most cases, the diagnosis of AUA is made on samples obtained from nasal ciliated cells with little discomfort to the patient. However, no studies have been performed in the same patient to confirm whether nasal samples reflect bronchial ciliary changes. To answer this question and to determine whether it is necessary to sample bronchial cells for the diagnosis of ciliary dyskinesia, we investigated 12 patients (between the age of 5 and 63 yr) with chronic sputum production. The presence of situs inversus, bronchiectasis, chronic sinusitis, and sterility was investigated to determine an inherited disorder. Two groups were established: Group 1 = six patients with an inherited disorder and Group 2 = six patients without evidence of an inherited disorder. Samples were obtained by brushing or biopsy of nasal and bronchial mucosa and were processed for transmission electron microscopy. In Group 1, the mean AUA was 65.2 +/- 11.4%. The following predominant axonema...Continue Reading

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References

Jan 11, 1979·The New England Journal of Medicine·J M SturgessJ A Turner
Jul 23, 1976·Science·B A Afzelius
Sep 1, 1990·The American Review of Respiratory Disease·E EscudierJ Fleury-Feith
Aug 1, 1989·The American Journal of Anatomy·D A GaillardE S Puchelle
Jan 1, 1985·CRC Critical Reviews in Biochemistry·B A Afzelius

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Citations

Nov 17, 2010·Archives of Otolaryngology--head & Neck Surgery·Virginie Prulière-EscabasseGilles Roger
Jul 20, 2005·Lung·Kenneth W TsangWah K Lam
Jul 14, 2000·Respirology : Official Journal of the Asian Pacific Society of Respirology·K W TsangG Tipoe
Nov 1, 1996·The Laryngoscope·J Nuutinen
Oct 6, 1997·Acta Anaesthesiologica Scandinavica·G CapellierF Barale
Apr 3, 2001·American Journal of Respiratory and Critical Care Medicine·J C HoK W Tsang
Oct 31, 2002·American Journal of Respiratory and Critical Care Medicine·Estelle EscudierAndré Coste
Oct 13, 2012·Orphanet Journal of Rare Diseases·Jean-François PaponBruno Louis
Nov 20, 2009·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Giulia MantovaniGiovanni Vozzi
Apr 11, 2013·European Journal of Pediatrics·Christelle ValletAline Tamalet
Jun 16, 2015·Multidisciplinary Respiratory Medicine·Nicola CiancioGiuseppe Di Maria
Nov 12, 2014·Annual Review of Physiology·Ann E TilleyRonald G Crystal
Nov 16, 2016·Cells·Asma Yaghi, Myrna B Dolovich
Aug 19, 2000·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·M A WiolandJ F Bernaudin
Aug 19, 2003·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Laurent DoucetMargarida D Amaral
Oct 29, 1997·The Annals of Otology, Rhinology, and Laryngology·C ChapelinE Escudier
Dec 12, 2001·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·M PifferiA L Boner
Dec 16, 1998·The Journal of Allergy and Clinical Immunology·S L SpectorR A Nicklas

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