Do nerve impulses penetrate terminal arborizations? A pre-presynaptic control mechanism

Trends in Neurosciences
P D Wall

Abstract

Is there clear evidence that action potentials travelling in a parent axon reach all of their terminals? In spinal afferents, many fibres extend their arborizations beyond the area in which cells can be shown to respond to the afferents. In addition, impulses fail to propagate in the long-range reach of myelinated fibres in dorsal columns when a GABA-operated Cl- shunt in the terminals is operating. When the mechanism is immobilized by antagonists of GABAA receptors, impulse blockade is relieved. This suggests an additional control mechanism, which is located in axons proximal to the synaptic area. Such a control could focus or defocus those parts of a terminal arborization that affect postsynaptic cells.

References

Jan 1, 1990·Scandinavian Journal of Clinical and Laboratory Investigation. Supplementum·T F Lüscher
Jan 22, 1993·Science·S J Zhang, M B Jackson
Feb 16, 1965·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·B KATZ, R MILEDI

❮ Previous
Next ❯

Citations

Sep 20, 2006·Experimental Brain Research·Raúl E RussoJørn Hounsgaard
Oct 1, 1995·Trends in Neurosciences·A KoltaP Clavelou
Aug 22, 1997·Journal of Neuroscience Methods·P R MoutonL C Walker
Aug 17, 2001·Trends in Neurosciences·B Rudy, C J McBain
Feb 13, 1999·Progress in Neurobiology·M J Millan
Dec 6, 1996·Neuroscience Letters·M Lidierth, P D Wall
Jun 28, 2001·Brain Research Bulletin·G Székely
Jan 23, 1999·Current Opinion in Neurobiology·J P LundG Scott
Aug 17, 1999·Journal of Neurology, Neurosurgery, and Psychiatry·A Esteban, J Prieto
Aug 10, 2000·Proceedings of the National Academy of Sciences of the United States of America·C L CoxK Svoboda
Mar 18, 2003·The Journal of Physiology·Morten Raastad, Gordon M G Shepherd
Nov 14, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·William B J CaffertyStephen B McMahon
Nov 2, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Anne H LeeWilliam N Frost
Jul 1, 2005·Journal of Integrative Neuroscience·M D Goldfinger
Dec 19, 2007·The Journal of Comparative Neurology·Ya'ara LeflerMarshall Devor
Aug 1, 1995·Nature Medicine·K J Berkley, C H Hubscher
Mar 13, 2008·The Journal of Comparative Neurology·K ReinerM Devor
Apr 30, 2011·Physiological Reviews·Dominique DebanneGisèle Alcaraz
Nov 1, 1996·Pain·F Cervero, J M Laird
Jun 8, 2011·Journal of Neurochemistry·Vincent Leviel
Sep 18, 2012·Neurochemical Research·Salvador Quiróz-GonzálezIsmael Jiménez-Estrada

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.