PMID: 9169310Apr 1, 1997Paper

Do noradrenaline and serotonin differentially affect social motivation and behaviour?

European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology
A DubiniV Polin

Abstract

In a placebo-controlled 8-week study comparing the selective noradrenaline re-uptake inhibitor (NARI), reboxetine, with the selective serotonin reuptake inhibitor (SSRI), fluoxetine, in major depression, patient social motivation and behaviour were investigated through a newly developed 21-item self-rating scale, the Social Adaptation Self-evaluation Scale (SASS). At last assessment the mean SASS total score was significantly superior on both reboxetine (n = 103) and fluoxetine (n = 100) compared with on placebo (n = 99). In addition, the SASS total score in the reboxetine group was significantly higher compared with the fluoxetine group. At point-biserial correlation analysis, all but one item discriminated reboxetine from placebo, while only 12 items discriminated fluoxetine from placebo. In the reboxetine-fluoxetine comparison, nine items showed a positive association with reboxetine, while the opposite was never seen; the association was maximal in the area of negative self perception and lack of motivation towards action. These results support, at social functioning level, a differential effect of selective manipulation of the noradrenergic or serotonergic system in keeping with the long-debated hypothesis on the specific ...Continue Reading

References

Apr 1, 1979·The British Journal of Psychiatry : the Journal of Mental Science·S A Montgomery, M Asberg
Sep 1, 1976·Archives of General Psychiatry·M M Weissman, S Bothwell
Aug 1, 1988·The American Journal of Psychiatry·J H KocsisJ Sweeney
Jun 1, 1974·Archives of General Psychiatry·M M WeissmanB Hanson
Apr 12, 1996·Journal of Affective Disorders·J B Leader, D N Klein
Dec 13, 1995·Journal of Affective Disorders·R A BurnsM T Abou-Saleh
Apr 1, 1997·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·M BoscV Polin
Feb 1, 1960·Journal of Neurology, Neurosurgery, and Psychiatry·M HAMILTON

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Citations

Jan 26, 2000·Comprehensive Psychiatry·M Bosc
Jul 6, 2000·European Psychiatry : the Journal of the Association of European Psychiatrists·H J Möller
Sep 5, 2001·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·A J Bond
Apr 1, 1997·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·B E Leonard
Apr 1, 1997·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·M BoscV Polin
May 25, 2005·Journal of Child and Adolescent Psychopharmacology·Tamar MozesAbraham Weizman
Feb 23, 2007·Annals of General Psychiatry·Nahathai WongpakaranDiana Clarke
Jul 14, 2011·Neuropsychiatric Disease and Treatment·Siegfried KasperAlexandra Kutzelnigg
Jan 13, 2006·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Richard M WoodRobert D Rogers
Mar 3, 2009·Journal of Affective Disorders·Richard TranterIan M Anderson
Sep 8, 2015·Journal of Affective Disorders·Kaloyan KamenovJosé Luis Ayuso-Mateos
Mar 16, 2001·Expert Opinion on Pharmacotherapy·S KasperE Hilger
Mar 29, 2002·The Annals of Pharmacotherapy·Rajamannar Ramasubbu
Jan 1, 1998·International Journal of Psychiatry in Clinical Practice·R HirschfeldS Montgomery
Jan 1, 1999·International Journal of Psychiatry in Clinical Practice·S ArgyropoulosD Nutt
Jul 23, 2003·Journal of Psychopharmacology·Wai S Tse, Alyson J Bond
Jul 19, 2008·Journal of Psychopharmacology·C MoretM Briley
Jan 27, 2005·Journal of Psychopharmacology·Wai S Tse, Alyson J Bond
Aug 13, 2002·Journal of Clinical Psychopharmacology·Stephen M StahlGerri E Schwartz
Aug 13, 2002·Journal of Clinical Psychopharmacology·Vittorino AndreoliMarcio Versiani
Oct 18, 2019·Yeungnam University Journal of Medicine·Hye-Geum KimEun-Jin Cheon
Oct 31, 2002·Human Psychopharmacology·Sidney H KennedyR Michael Bagby
Dec 20, 2002·International Clinical Psychopharmacology·James M FergusonGerri E Schwartz
Sep 14, 2000·International Journal of Geriatric Psychiatry·E Aguglia
Oct 29, 2014·Journal of Animal Science·R L DennisD C Lay

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