Do oral contraceptives affect young women's memory? Dopamine-dependent working memory is influenced by COMT genotype, but not time of pill ingestion.

PloS One
Laura GravelsinsGillian Einstein

Abstract

Despite the widespread use of oral contraceptives (OCs), and the well-documented influence of estrogens, notably 17β-estradiol (E2), on cognition, research relating OCs to working memory is limited and mixed. Two factors may contribute to these mixed findings: 1) pharmacokinetics of oral contraceptives, which drive fluctuations in synthetic hormone levels; and 2) genetic polymorphisms related to dopamine degradation and working memory, which interact with E2. This research investigated whether the pharmacokinetics of oral contraceptives, in concert with the single nucleotide polymorphism (Val158Met; rs4680) of the catechol-o-methyltransferase gene (COMT), influence working memory performance. University-age women taking and not taking OCs were tested for working memory and genotyped for COMT. If they were not taking OCs (n = 62), sessions occurred in the early follicular (low E2) and late follicular (high E2) phase. If they were taking OCs (n = 52), sessions occurred 1-2 hours after (high ethinyl estradiol, EE) and ~24 hours after (low EE) pill ingestion. Working memory was tested using the N-back, AX-CPT, Digit Span, and Digit Ordering Tasks. Data were analyzed using multilevel models with estrogen condition, COMT, and group a...Continue Reading

References

Oct 1, 1992·Psychoneuroendocrinology·S M Phillips, B B Sherwin
Dec 1, 1972·American Journal of Obstetrics and Gynecology·D R MishellS C Stone
Feb 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·M PetridesA C Evans
Apr 4, 2000·Toxicological Sciences : an Official Journal of the Society of Toxicology·R M BlairD M Sheehan
Apr 2, 2002·The American Journal of Psychiatry·Anil K MalhotraDavid Goldman
Sep 11, 2002·Human Reproduction Update·A M van Heusden, B C J M Fauser
Dec 10, 2002·Neuroscience and Biobehavioral Reviews·Todd S Braver, Deanna M Barch
Oct 1, 1956·Journal of Consulting Psychology·L H BECKI SARASON
Apr 1, 1958·Journal of Experimental Psychology·W K KIRCHNER
Sep 24, 2004·Progress in Neurobiology·Jeremy K Seamans, Charles R Yang
May 21, 2008·Experimental and Clinical Psychopharmacology·Whitney WhartonCarey Gleason
Aug 9, 2008·Neuropsychologia·Ahmed A MoustafaMichael J Frank
Apr 22, 2009·Proceedings of the National Academy of Sciences of the United States of America·Todd S BraverDeanna M Barch
Aug 29, 2009·Behavioural Brain Research·Roberto Rodriguez-JimenezTomas Palomo
Jun 17, 2010·Brain Research·Belinda PletzerHubert H Kerschbaum
Aug 21, 2010·Nature Reviews. Neuroscience·Daniel A HackmanMichael J Meaney
Apr 8, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Emily Jacobs, Mark D'Esposito
May 3, 2011·Biological Psychiatry·Roshan Cools, Mark D'Esposito
Jan 17, 2012·Trends in Cognitive Sciences·Todd S Braver
Apr 17, 2012·Psychoneuroendocrinology·Magdalena BuckertChristian J Fiebach
May 27, 2014·Contraception·Annabelle M WarrenJayashri Kulkarni
Nov 13, 2015·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Francesco PapaleoGianfranco Spalletta
Apr 4, 2016·Neuroscience and Biobehavioral Reviews·Liisa A M GaleaElena Choleris
Nov 3, 2016·JAMA Psychiatry·Charlotte Wessel SkovlundØjvind Lidegaard

❮ Previous
Next ❯

Software Mentioned

lme4
Inquisit
stats

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2021 Meta ULC. All rights reserved