Do patients with a failed metal-on-metal hip implant with a pseudotumor present differences in their peripheral blood lymphocyte subpopulations?

Clinical Orthopaedics and Related Research
Isabelle CatelasPaul E Beaulé

Abstract

Early adverse tissue reactions around metal-on-metal (MoM) hip replacements, especially pseudotumors, are a major concern. Because the causes and pathomechanisms of these pseudotumors remain largely unknown, clinical monitoring of patients with MoM bearings is challenging. The purpose of this study was to compare the lymphocyte subpopulations in peripheral blood from patients with a failed MoM hip implant with and without a pseudotumor and patients with a well-functioning MoM hip implant without a pseudotumor. Potential differences in the systemic immune response are expected to reflect local differences in the periprosthetic tissues. Consenting patients who underwent a revision of a failed MoM hip implant at The Ottawa Hospital (TOH) from 2011 to 2014, or presented with a well-functioning MoM hip implant for a postoperative clinical followup at TOH from 2012 to 2013, were recruited for this study, unless they met any of the exclusion criteria (including diagnosed conditions that can affect peripheral blood lymphocyte subpopulations). Patients with a failed implant were divided into two groups: those with a pseudotumor (two hip resurfacings and five total hip arthroplasties [THAs]) and those without a pseudotumor (10 hip resurf...Continue Reading

References

Mar 1, 1981·International Journal of Dermatology·K Merritt, S A Brown
Apr 1, 1994·The Journal of Investigative Dermatology·F Sinigaglia
May 1, 1996·Journal of Biomedical Materials Research·J Yang, K Merritt
Aug 1, 1996·Clinical Orthopaedics and Related Research·K Merritt, S A Brown
Dec 4, 2004·The Journal of Arthroplasty·Joshua J JacobsHarlan C Amstutz
Jan 8, 2005·The Journal of Bone and Joint Surgery. American Volume·Hans-Georg WillertChristoph H Lohmann
Mar 1, 2005·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Nadim James HallabJoshua J Jacobs
Jun 9, 2007·The American Journal of Pathology·Rei WatanabeKunihiko Tamaki
Jul 25, 2007·Biomaterials·Stuart B Goodman
Oct 20, 2007·Biological Reviews of the Cambridge Philosophical Society·Shinichi Nakagawa, Innes C Cuthill
Feb 15, 2008·Journal of Orthopaedic Surgery and Research·Nadim James HallabJoshua J Jacobs
Jul 2, 2008·The Journal of Bone and Joint Surgery. British Volume·H PanditD W Murray
Aug 5, 2009·The Journal of Bone and Joint Surgery. British Volume·G GrammatopoulosH S Gill
Mar 2, 2010·The Journal of Bone and Joint Surgery. British Volume·Y-M KwonD W Murray
May 12, 2010·Clinical Orthopaedics and Related Research·Pat CampbellHarlan C Amstutz
Mar 26, 2011·The Orthopedic Clinics of North America·Edward EbramzadehHarlan C Amstutz
Aug 10, 2011·Journal of Experimental Psychology. General·Catherine O FritzJennifer J Richler
Oct 5, 2011·The Journal of Bone and Joint Surgery. British Volume·A J HartJ A Skinner
Dec 14, 2011·The Journal of Bone and Joint Surgery. American Volume·Daniel H WilliamsDonald S Garbuz
Mar 29, 2013·Clinical Orthopaedics and Related Research·Sulaiman A AlmousaDonald S Garbuz
Apr 11, 2013·Clinical Orthopaedics and Related Research·Jacob T MunroDonald S Garbuz
Jun 21, 2013·The Journal of Bone and Joint Surgery. American Volume·George GrammatopoulosNicholas Athanasou
Jul 23, 2013·Clinical Orthopaedics and Related Research·Donald S GarbuzBruce B Forster
Nov 22, 2013·The Journal of Bone and Joint Surgery. American Volume·Eric Y ChangChristine B Chung
Aug 22, 2014·Clinical Orthopaedics and Related Research·Edward EbramzadehSophia N Sangiorgio

❮ Previous
Next ❯

Citations

Mar 27, 2019·Critical Reviews in Toxicology·Michael KovochichDennis J Paustenbach
Jul 23, 2019·Hip International : the Journal of Clinical and Experimental Research on Hip Pathology and Therapy·David MarkelWei-Ping Ren
Sep 18, 2020·Zeitschrift für Orthopädie und Unfallchirurgie·Anastasia Rakow, Janosch Schoon
Nov 14, 2017·Critical Reviews in Toxicology·Donatella GranchiNicola Baldini
Aug 17, 2019·Frontiers in Bioengineering and Biotechnology·Felipe EltitRizhi Wang
Dec 24, 2019·Hip International : the Journal of Clinical and Experimental Research on Hip Pathology and Therapy·Inari LaaksonenHenrik Malchau
Jan 29, 2021·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Felipe EltitMichael E Cox

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Biology: Molecular Imaging

Molecular imaging enables noninvasive imaging of key molecules that are crucial to tumor biology. Discover the latest research in molecular imaging in cancer biology in this feed.

© 2021 Meta ULC. All rights reserved