PMID: 8582070Oct 1, 1995Paper

Do patients with epistaxis have drug-induced platelet dysfunction?

Clinical Otolaryngology and Allied Sciences
J R LiveseyP J Kesteven

Abstract

Aspirin and other non-steroidal anti-inflammatory drugs (NSAID) are being used increasingly. A positive correlation has been shown between epistaxis and the use of NSAID in the over 50s. This prospective study compared the NSAID intake and platelet function in 50 patients with epistaxis and 50 controls. Standard haematological parameters and the platelet response to collagen and arachidonic acid aggregation and adenosine triphosphate release were measured. The patients showed a significant increase in NSAID intake (P < 0.01, 95% confidence for the difference in the medians = 4-36%) and hypertension (for diastolic blood pressure > 100 mmHg, P < 0.01, 95% confidence for the difference in the medians = 5.9-16.1). The patients showed a significant reduction in platelet aggregation to collagen (P = 0.025). Non-steroidal anti-inflammatory drugs produce a significant platelet dysfunction which should be considered in the multifactorial aetiology of epistaxis.

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Citations

Jul 2, 1999·The American Journal of Medicine·A I Schafer
Oct 31, 2009·The Laryngoscope·Michael B SoykaDavid Holzmann
Mar 25, 1999·Revista clínica española·E Calvo BoizasF Gómez Toranzo
Aug 26, 1998·The Annals of Otology, Rhinology, and Laryngology·H L TayT M MacDonald
Oct 7, 2008·British Journal of Hospital Medicine·Louise Melia, Gerald McGarry
Mar 3, 2007·British Journal of Hospital Medicine·Matthew I TrotterAdrian Drake-Lee

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