Do patients with interictal migraine modulate pain differently from healthy controls? A psychophysical and brain imaging study

Pain
Lee B KislerIrit Weissman-Fogel

Abstract

Studies in interictal migraine show either normal or impaired pain modulation, at the psychophysical level. To date, pain modulation in migraineurs has yet to be explored concurrent with imaging methods. We aimed to investigate brain activity associated with endogenous analgesia by functional magnetic resonance imaging in attack-free migraineurs. Thirty-nine episodic migraineurs and 35 controls participated. Endogenous analgesia efficiency was assessed by the conditioned pain modulation (CPM) paradigm during functional magnetic resonance imaging. Conditioned pain modulation included 4 stimulation sequences of either test stimulus (noxious contact heat at forearm) given stand alone (Ts_alone) or concomitant to contralateral foot immersion in cold water (Ts_conditioned). The psychophysical CPM (Ts_conditioned minus Ts_alone; 0-10 numerical rating scale) and related brain activity were examined. No group differences were found in the psychophysical CPM (controls: -0.52 ± 0.80; migraineurs: -0.20 ± 0.88; repeated-measures analysis of variance: P = 0.110) or related brain activity (family wise error [P < 0.05] correction at the voxel level). Within groups, controls showed a significant CPM effect (Ts_alone: 6.15 ± 2.03 vs Ts_conditi...Continue Reading

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Citations

Jan 10, 2019·Pain·Hadas Nahman-AverbuchRobert C Coghill
Oct 11, 2019·Journal of Neural Transmission·Gianluca CoppolaFrancesco Pierelli
Nov 7, 2019·Pain·Tibor M SzikszayKerstin Luedtke
Oct 22, 2019·Frontiers in Neurology·Péter FaragóZsigmond Tamás Kincses
Nov 25, 2020·Headache·Hadas Nahman-AverbuchChristopher D King
Feb 27, 2021·Scientific Reports·Pablo de la CobaGustavo A Reyes Del Paso
Apr 2, 2021·Journal of Pain Research·Miriam KunzStefan Lautenbacher

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