Do patients with oxyphilic cell papillary thyroid carcinoma have a poor prognosis? Analysis of the surveillance, epidemiology, and end results database 2004-2013 with propensity score matching

Oncotarget
Chunping LiuTao Huang

Abstract

The prognosis of oxyphilic cell papillary thyroid carcinoma (OCPTC) remains unclear. The aim of this study was to investigate the prognosis of OCPTC and provide a new perspective on treatment guidelines for these patients. We investigated a large cohort of DTC patients from the Surveillance, Epidemiology, and End Results (SEER) database between 2004 and 2013. Patient mortality was examined by Kaplan-Meier analyses with log-rank tests and Cox proportional hazards regression analyses. In the study cohort, the rate of cancer-specific mortality per 1000 person-years for OCPTC was lower than that for classic papillary thyroid cancer (CPTC) and follicular thyroid cancer (FTC). According to the multivariate Cox regression model, the cancer-specific and all-cause mortality rates of OCPTC were similar to that of CPTC and FTC. The cancer-specific survival rate in patients with OCPTC was higher than that in patients with FTC, but similar to patients with CPTC, after matching for influential factors using propensity score matching analysis. The unanticipated prognosis provided new implications for the treatment of patients with OCPTC.

References

Jul 18, 2001·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·M VolanteG Bussolati
Nov 5, 2003·Journal of Endocrinological Investigation·E AllìaM Papotti
Jul 27, 2004·Antimicrobial Agents and Chemotherapy·Spotswood L SpruanceMatthew Samore
Oct 1, 2004·World Journal of Surgery·Adolfo PisanuAlessandro Uccheddu
Jan 28, 2012·CA: a Cancer Journal for Clinicians·Edgar P SimardAhmedin Jemal
Apr 25, 2012·Thyroid : Official Journal of the American Thyroid Association·Justin A BishopWilliam H Westra
Aug 16, 2012·Cancer·Paolo GoffredoJulie A Sosa
Jan 30, 2013·American Journal of Otolaryngology·Roy HodJacob Shvero
Feb 23, 2013·Nature Reviews. Cancer·Mingzhao Xing
Apr 2, 2013·The Journal of Clinical Endocrinology and Metabolism·Ian GanlyTimothy A Chan
May 15, 2013·Lancet·Mingzhao XingMartin Schlumberger
Oct 22, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Mingzhao XingVlasta Sýkorová
Nov 15, 2014·Population Studies·Heidi A HansonC Janna Harrell
Jan 26, 2016·CA: a Cancer Journal for Clinicians·Wanqing ChenJie He
Feb 27, 2016·Endocrine-related Cancer·Yushan Mao, Mingzhao Xing
Nov 23, 2016·Endocrine-related Cancer·Xiaopei ShenMingzhao Xing
Dec 22, 2016·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Mohamed Abdelgadir AdamJulie A Sosa
Jan 8, 2017·Endocrine-related Cancer·Luca MorandiSofia Asioli
Apr 1, 2017·JAMA : the Journal of the American Medical Association·Hyeyeun LimCari M Kitahara

❮ Previous
Next ❯

Citations

Aug 15, 2019·European Journal of Nuclear Medicine and Molecular Imaging·Vera WenterAndrei Todica

❮ Previous
Next ❯

Methods Mentioned

BETA
dissection

Software Mentioned

/ SE
GraphPad Prism
SPSS
Stata

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.