Do patients with ulcerative colitis diagnosed at a young age have more severe disease activity than patients diagnosed when older?

Digestion
Jin Ha LeeWon Ho Kim

Abstract

To compare the clinical features and disease behavior of ulcerative colitis (UC) according to the age at onset. This retrospective study included 455 patients with UC who were diagnosed and treated between 1990 and 2008 at a single tertiary institution in Korea. The patients were divided into 2 groups according to their age at diagnosis of UC: an elderly group (>or=40 years) and a young group (<40 years). Clinical findings at diagnosis, extent of disease, treatment modalities used, cumulative admission rates, cumulative relapse rates, and surgery rates were analyzed according to these age groups. Two hundred and forty-two patients with UC (53.2%) were diagnosed before the age of 40 years. Disease severity at initial presentation as assessed by diarrhea frequency, the presence of pancolitis, and the use of steroids were higher in the young group; however, clinical disease course including cumulative admission rates, cumulative relapse rates, and surgery rates were not significantly different between the 2 groups. Certain clinical features and the extent of disease in UC patients appear to be more severe when the disease is diagnosed at younger age; however, their disease course and prognosis might not be different from those of ...Continue Reading

Citations

Mar 1, 2012·Digestive Diseases and Sciences·Sandra M Quezada, Raymond K Cross
Dec 15, 2012·Clinical and Translational Gastroenterology·Jean-Francois TurcotteJulia J Liu
Apr 14, 2012·Journal of Gastroenterology and Hepatology·Lani PrideauxSiew C Ng
Jan 25, 2013·World Journal of Gastroenterology : WJG·Han Ho JeonJae Hee Cheon
Mar 8, 2013·World Journal of Gastroenterology : WJG·Mi-Kyung Sung, Mi-Young Park
Jan 29, 2011·Journal of Crohn's & Colitis·Peter Laszlo LakatosLaszlo Lakatos
Feb 20, 2016·Scandinavian Journal of Gastroenterology·Jae Hyun KimWon Ho Kim
Jan 16, 2013·European Journal of Internal Medicine·Ismail Hakkı KalkanAysel Ulker
Mar 2, 2016·Journal of Crohn's & Colitis·Ashwin N AnanthakrishnanSiew C Ng
Apr 16, 2014·Journal of Gastroenterology and Hepatology·Haruhiko TakahashiMasakazu Washio
May 14, 2016·Intestinal research·Wee Khoon NgSiew C Ng
Aug 25, 2016·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Simona DeianaVito Annese
Sep 21, 2016·Journal of Crohn's & Colitis·Monica CesariniSimon P L Travis
Dec 25, 2016·Digestive Diseases and Sciences·Mimi C TanJason K Hou
Jan 13, 2017·Inflammatory Bowel Diseases·Gabriella VeloniasAshwin N Ananthakrishnan
Jan 24, 2018·European Journal of Gastroenterology & Hepatology·Denise HerzogUNKNOWN Swiss IBD Cohort Study Group
Feb 6, 2018·Journal of Pediatric Gastroenterology and Nutrition·Katherine LiJoshua R Friedman
Sep 11, 2014·World Journal of Gastroenterology : WJG·Soo Jung ParkJae Hee Cheon
Sep 26, 2014·World Journal of Gastroenterology : WJG·Andreas StallmachCarsten Schmidt
Dec 12, 2013·Scandinavian Journal of Gastroenterology·Bun KimJae Hee Cheon
Jul 30, 2014·World Journal of Gastroenterology : WJG·Bruno César da SilvaGenoile Oliveira Santana

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