Do polyomavirus hominis strains BK and JC play a role in oral squamous cell carcinoma?

Annals of Agricultural and Environmental Medicine : AAEM
Dorota PolzMałgorzata Polz-Dacewicz

Abstract

Head and neck cancers are the most common cancers worldwide. It is estimated that approximately 90% of all head and neck cancers are represented by squamous cell carcinoma (SCC). There are many risk factors causing this type of cancer, including environmental factors and lifestyle choices, such as tobacco smoking or abusing alcohol. Other important risk factor include infectious factors. The aim of this study was to analyze the prevalence of BK and JC virus infections among patients with oral squamous cell carcinoma (OSCC). The correlation between BKV infection and OSCC, and correlation between BKV, OSCC, alcohol abuse, tobacco smoking, demographic data, pre-treatment staging, metastases of lymph node evidence, and grading, was analyzed. The study group consisted of 92 patients with squamous cell carcinoma (OSCC), 75 males, and 17 females, aged between 40 - 87 (average 56.8). All the patients underwent surgery and were not subjected to chemotherapy or radiotherapy prior to treatment. The analyzed samples were collected from paraffin sections. BKV DNA was detected in 18.5% of patients with OSCC. In the control group, BKV DNA was detected in 3.3%. BKV DNA was statistically more frequently detected among patients with squamous car...Continue Reading

Citations

Jul 18, 2015·Cancers·Raquel Burger-Calderon, Jennifer Webster-Cyriaque
Sep 30, 2016·World Journal of Transplantation·Darlene VigilAntonios H Tzamaloukas
Feb 10, 2018·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·Michael AuerFlorian Deisenhammer
Jun 2, 2018·Oncotarget·Leonard PoluschkinStina Syrjänen
Apr 21, 2018·International Journal of Molecular Sciences·Zuzana Vojtechova, Ruth Tachezy
Feb 1, 2020·Infectious Agents and Cancer·Juan P MuñozFrancisco Aguayo

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