Do primary neuroendocrine tumors and metastasis have the same characteristics?

The Journal of Surgical Research
Erika B LindholmEugene A Woltering

Abstract

Only one tumor site is usually biopsied to determine the histologic features of that patient's entire tumor burden. We hypothesized that there are significant histologic and functional differences in primary neuroendocrine tumors (NETS) and their nodal or organ metastases. We also hypothesized that limited tumor sampling could lead to erroneous assumptions about the tumor's histologic characteristics and clinical behavior. Thirteen patients with metastatic well differentiated midgut NETS underwent simultaneous removal of their primary tumor, nodal metastasis, and organ metastasis. Each tumor site was stained quantitatively for Ki-67, chromogranin A (CGA), synaptophysin, CD31, and Factor VIII. Samples were also evaluated with in vitro tumor angiogenesis and drug chemoresistance assays. Ki-67 staining was nearly identical at all sites tested. Quantitative stains for CGA, synaptophysin, cluster of differentiation 31 (CD31), and Factor VIII varied considerably among the patient's three tissue site samples. Only 6% of the tissue samples tested against a battery of chemotherapeutic agents exhibited susceptibility to a single drug at all three tumor sites. In contrast, several antiangiogenic agents exhibited uniform effectiveness acro...Continue Reading

References

May 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·B WiedenmannV E Gould
Jul 20, 2001·British Journal of Cancer·J C WatsonE A Woltering
Jun 27, 2008·Cellular and Molecular Life Sciences : CMLS·H Lage
Nov 10, 2009·Targeted Oncology·Jaume Capdevila, Ramon Salazar
Nov 26, 2010·Endocrinology and Metabolism Clinics of North America·John LyonsEugene A Woltering

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Citations

Aug 5, 2014·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·S SinghC H L Law

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