PMID: 6404866Mar 1, 1983Paper

Do prostatic biopsies 12 months or more after external irradiation for adenocarcinoma, Stage III, predict long-term survival?

International Journal of Radiation Oncology, Biology, Physics
J D Cox, R W Kline

Abstract

Serial biopsies of the prostate after high dose external irradiation for adenocarcinoma show a gradual disappearance of the neoplastic cells. With such treatment, results of the biopsies do not have any short term prognostic significance. However, positive biopsies 12 months or more after treatment are reputed to be an unfavorable sign for long-term survival. From August, 1970 through February, 1974, 46 consecutive patients with locally advanced (Stage III, C, or T3 and T4) adenocarcinoma of the prostate underwent external irradiation with 2 MV X rays or cobalt-60 teletherapy. The technique included parallel, opposed, 14 X 14 cm anterior and posterior fields, and a 10 X 14 cm perineal field. The center of the prostate received a total dose of 70 Gy in 30-37 fractions in 43 to 56 days. Details of the dosimetry reveal inhomogeneity of the dose of +/- 7% within an enlarged prostate. With a median follow-up of 8 years, the actuarial survival rates, uncorrected for death from intercurrent disease, are 69% at 5 years and 49% at 10 years. Biopsies of the prostate 12 months or more after treatment were available from 31 patients: 19 had one or more positive biopsies and 12 had consistently negative biopsies; the survival curves are ide...Continue Reading

Citations

May 22, 2010·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·David Eriksson, Torgny Stigbrand
Dec 1, 1995·International Journal of Radiation Oncology, Biology, Physics·A MartinezD Brabbins
Aug 3, 2001·International Journal of Radiation Oncology, Biology, Physics·S SmathersL True
May 23, 2002·International Journal of Radiation Oncology, Biology, Physics·Alvaro A MartinezFrank Vicini
Oct 1, 1996·International Journal of Radiation Oncology, Biology, Physics·E M HorwitzA A Martinez
Jan 15, 1997·International Journal of Radiation Oncology, Biology, Physics·J LaverdièreF Labrie
Dec 26, 2001·Proceedings of the National Academy of Sciences of the United States of America·Bey-Dih ChangIgor B Roninson
May 1, 1985·The British Journal of Radiology·H J Dobbs, J E Husband
Jan 1, 1992·International Journal of Radiation Oncology, Biology, Physics·B R PrestidgeM A Bagshaw
Jan 1, 1992·International Journal of Radiation Oncology, Biology, Physics·P P LaiM A Lockett
Sep 1, 1990·International Journal of Radiation Oncology, Biology, Physics·A G MeekL Wielopolski
Oct 1, 1986·International Journal of Radiation Oncology, Biology, Physics·T F DeLaneyG R Prout
Jul 1, 1987·International Journal of Radiation Oncology, Biology, Physics·M C RounsavilleM M Heltzel
Aug 14, 2013·NMR in Biomedicine·V Y ZhangJ Kurhanewicz
Dec 1, 1985·British Journal of Urology·A W RitchieG D Chisholm
Jun 1, 1996·Hematology/oncology Clinics of North America·P Lillis, I M Thompson
Sep 1, 1990·International Journal of Radiation Oncology, Biology, Physics·P P LaiM A Lockett
Apr 13, 2004·Oncogene·Jerry W Shay, Igor B Roninson
Jul 1, 2020·International Journal of Molecular Sciences·Marina FrancisYoussef H Zeidan
Jan 1, 1986·Scandinavian Journal of Urology and Nephrology·P T Scardino
Aug 5, 1998·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·S Dinges
Sep 5, 1998·Cancer Treatment Reviews·M Reni, A Bolognesi
Jan 1, 1994·International Journal of Radiation Oncology, Biology, Physics·C N ColemanR Gelman

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.