Do retroperitoneal extragonadal germ cell tumours exist?

Canadian Urological Association Journal = Journal De L'Association Des Urologues Du Canada
Nahid PunjaniNicholas Power

Abstract

Extragonadal germ cell tumours (GCTs) have been described arising in midline structures. Although primary retroperitoneal extragonadal GCTs (RPGCTs) comprise 30% to 40% of these, their existence as a genuine disease has been questioned. Our study evaluated clinicopathological findings to examine this question in RPGCT patients at our centre. Data from 414 men between 1980 and 2014 treated at London Health Sciences Centre with chemotherapy for testicular GCTs were reviewed retrospectively. Primary RPGCT was defined as pathologically diagnosed GCT with no evidence of GCT in the testes by physical exam or ultrasound. Patients thought to have primary RPGCT at the time of initial diagnosis were identified from an electronic database and data were extracted. In total, 18 men with a diagnosis of metastatic RPGCT were identified. Four were excluded due to ultrasound reports that were incomplete or suggested malignancy. The remaining 14 patients had negative or non-specific ultrasounds, and all received platinum-based combination chemotherapy. Ten patients (71%) underwent post-chemotherapy RP lymph node dissections; of those 8 (57%) who underwent orchiectomy, none had corresponding pathologically normal testicular tissue. RPGCT patients...Continue Reading

Citations

Dec 6, 2019·Journal of the National Comprehensive Cancer Network : JNCCN·Timothy GilliganLenora A Pluchino
Mar 12, 2021·Current Oncology·Arnon LaviNicholas E Power
Aug 14, 2021·Critical Reviews in Oncology/hematology·Giovanni Maria IannantuonoFrancesco Torino

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Imaging

Imaging techniques, including CT and MR, have become essential to tumor detection, diagnosis, and monitoring. Here is the latest research on cancer imaging.