PMID: 6105763Jan 1, 1980Paper

Do schizophrenics well adapted in the community need neuroleptics? A depot neuroleptic withdrawal study

Acta Psychiatrica Scandinavica. Supplementum
S J DenckerU Malm

Abstract

Two depot neuroleptics (flupenthixol plamitate and clopenthixol decanoate) used for at least 15 months were withdrawn in 32 schizophrenic outpatients belonging to the most symptom-free and social cohort of a total patient population. They all had only slight schizophrenic symptoms, were well adapted in the community, and had been free from relapse for at least 2 years before the study. They were assessed by means of rating scales every month during the first six months and then after 9 and 12 months. After the one-year trial 26 patients had relapsed. Moreover, after the control period further 4 out of 6 patients relapsed during the following drug-free year. These results indicate the necessity of a long follow-up period after withdrawal of depot neuroleptics. Moreover, the results suggest that periodical drug-free periods of about 3 months are appropriate in symptom-poor patients during long-term treatment with long-acting antipsychotic drugs.

References

Jan 1, 1976·The American Journal of Psychiatry·G Gardos, J O Cole
Feb 1, 1978·Acta Psychiatrica Scandinavica·S J DenckerU Malm
Feb 1, 1978·Acta Psychiatrica Scandinavica·S J DenckerU Malm
Jan 1, 1978·Schizophrenia Bulletin·W T Carpenter
Jan 1, 1978·Acta Psychiatrica Scandinavica. Supplementum·M AsbergG Sedvall
Jan 1, 1970·Acta Psychiatrica Scandinavica. Supplementum·G M Simpson, J W Angus
Jun 1, 1969·The British Journal of Psychiatry : the Journal of Mental Science·R F PrienN F Belkin
Feb 1, 1960·Journal of Neurology, Neurosurgery, and Psychiatry·M HAMILTON

❮ Previous
Next ❯

Citations

May 31, 2001·Acta Psychiatrica Scandinavica·L J Bosveld-van HaandelR J van den Bosch

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antipsychotic Drugs

Antipsychotic drugs are a class of medication primarily used to manage psychosis (including delusions, hallucinations, paranoia or disordered thought), principally in schizophrenia and bipolar disorder. Discover the latest research on antipsychotic drugs here