PMID: 9165405Mar 1, 1997Paper

Do seizures beget seizures? An assessment of the clinical evidence in humans

Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society
A T Berg, S Shinnar

Abstract

For more than a century, epilepsy was characterized as a chronic disease, with little chance of remission or cure. It was also considered a progressive disease in which seizures led to more seizures. Experimental work in animals provided additional support for the notion that seizures could beget seizures. However, the earliest clinical observations in humans were based on highly selected, largely refractory patients. Furthermore, the experimental work in animals bore little relation to naturally occurring seizures and epilepsy in humans. Evidence from multiple sources regarding the nature and natural history of seizures and epilepsy in humans has repeatedly demonstrated that in most cases of occurrence of seizures itself does not influence the long-term outcome of epilepsy. Consequently, interventions to prevent seizures early in the course of a seizures disorder do not alter the natural history of seizure disorders with respect to whether remission will occur in the long term. That outcome is largely predetermined by other factors, many of which are not currently amenable to intervention. In some rare syndromes, deterioration is progressive. In these instances, it is the underlying syndrome, not the seizures, that is primaril...Continue Reading

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Citations

Sep 3, 2002·Annals of Neurology·Michelle T LiebregtsL Stan Leung
Apr 18, 1998·Annals of Neurology·S Shinnar
Feb 20, 2002·Trends in Neurosciences·Annad d H RatzliffIvan Soltesz
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Jan 19, 2006·Epilepsia·Frank W Drislane
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Jun 24, 2008·European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society·Willem F M Arts, Ada T Geerts

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