PMID: 10724641Mar 21, 2000

Do sinusoidal models of respiration accurately reflect the respiratory events of patients breathing on nebulizers?

Journal of Aerosol Medicine : the Official Journal of the International Society for Aerosols in Medicine
A L CoatesL C Lands


The amount of drug that is delivered by nebulization is a combination of the physical properties of the agent being nebulized, the performance of the nebulizer, and the pattern of breathing of the patient. To avoid biological variation, mechanical models of breathing are frequently employed during the evaluation of the performance of a device. For simplicity, many investigators use sinusoidal models of breathing to calculate the expected inhaled mass, although some use square waves and other more complex models. Most assume that the duration of inspiration (Ti) is half of the total respiratory time (Ttot). This study compared the calculated inhaled mass from which the expected pulmonary deposition was estimated from the actual pattern of breathing of 43 children with cystic fibrosis (CF) breathing from an unvented nebulizer with a low dead volume and appropriate particle size distribution with that from a sinusoidal pattern of breathing using the same tidal volume (VT) and respiratory rate. The respiratory duty cycle (Ti/Ttot) was 0.45 +/- 0.05, which meant that less time was spent during inspiration than that found in a pure sinusoidal pattern. The difference between the predicted deposition from the actual pattern of breathin...Continue Reading


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Jan 17, 2002·Journal of Aerosol Medicine : the Official Journal of the International Society for Aerosols in Medicine·S L HoA L Coates
Nov 7, 2000·Journal of Aerosol Medicine : the Official Journal of the International Society for Aerosols in Medicine·A L CoatesL C Lands
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Apr 17, 2013·Journal of Aerosol Medicine and Pulmonary Drug Delivery·A L CoatesSharon D Dell
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