Do specific neurocognitive deficits predict specific domains of community function in schizophrenia?

The Journal of Nervous and Mental Disease
D I VelliganL C Halgunseth

Abstract

We examined whether specific neurocognitive deficits predicted specific domains of community outcome in 40 schizophrenic patients. Neuropsychological assessments were conducted before hospital discharge, and measures of functional outcome were obtained 1 to 3.5 years later. A priori hypotheses were generated based upon a recent review by Green (Green MF [1996] What are the functional consequences of neurocognitive deficits in schizophrenia? American Journal of Psychiatry, 153(3):321-330). As hypothesized, verbal memory predicted all measures of community outcome, vigilance predicted social outcomes, and executive functioning predicted work and activities of daily living (ADLs). However, in addition to the predicted relationships, many other associations were found between neuropsychological test scores and adaptive function. Furthermore, both cognitive and functional measures were intercorrelated. If deficits in adaptive functioning are neurocognitively multi-determined, utilizing compensatory strategies to bypass multiple areas of cognitive impairment may be more efficient than cognitive remediation in improving community outcomes.

References

Apr 1, 2011·Social Psychiatry and Psychiatric Epidemiology·Michela GiugiarioPaola Rocca
Sep 4, 2008·Psychopharmacology·Cherrie Galletly
Jul 17, 2007·European Archives of Psychiatry and Clinical Neuroscience·Michael RiedelHans-Jürgen Möller
Jul 17, 2007·European Archives of Psychiatry and Clinical Neuroscience·Michael RiedelHans-Jürgen Möller
Dec 5, 2008·European Archives of Psychiatry and Clinical Neuroscience·Wolfgang WölwerGerman Study Group on First Episode Schizophrenia
Oct 15, 2009·European Archives of Psychiatry and Clinical Neuroscience·Silvana GalderisiMario Maj
Jul 30, 2009·Neuropsychology Review·Barton W PalmerRobert K Heaton
Jul 15, 2003·Current Psychiatry Reports·J Daniel Ragland
Sep 18, 2001·Current Psychiatry Reports·Philip D HarveyJ I Friedman
Mar 31, 2004·Biological Psychiatry·Dwight DickinsonJames M Gold
Oct 8, 2004·Schizophrenia Research·Maria SemkovskaEmmanuel Stip
Aug 27, 2004·Schizophrenia Research·Jovier D EvansSandra Tunis
Jun 27, 2002·Schizophrenia Research·Dwight Dickinson, Robert D Coursey
Sep 24, 2010·Psychological Medicine·J W CarterS A Mednick
Mar 24, 2011·Psychological Medicine·A HoferW W Fleischhacker
Feb 20, 2008·Journal of the International Neuropsychological Society : JINS·Anja VaskinnOle A Andreassen
Nov 11, 2009·Journal of the International Neuropsychological Society : JINS·Frank LarøiMartial Van der Linden
Feb 12, 2011·Journal of the International Neuropsychological Society : JINS·Daniel V HoltStefan Kaiser
May 23, 2012·Neuropsychology·Kristan ArmstrongStephan Heckers
Sep 17, 2010·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Tyler A LeshCameron S Carter
Aug 4, 2006·Schizophrenia Bulletin·Anita PatelTil Wykes
Aug 19, 2006·Schizophrenia Bulletin·Volker RoderHans D Brenner
Apr 20, 2004·Clinical Neuropharmacology·Murray H Rosenthal, Sharon L Bryant
Jun 30, 2005·Journal of Psychiatric Practice·Jason E Schillerstrom
Jun 23, 2004·Journal of Clinical Psychopharmacology·Alexander BrunnauerHans-Jürgen Möller
Jun 24, 2003·The Journal of Nervous and Mental Disease·Rebecca S LancasterPaul H Lysaker
Jul 17, 2007·The Journal of Nervous and Mental Disease·Faith B DickersonRobert Yolken
Jul 1, 2011·The Journal of Nervous and Mental Disease·Ulla KarilampiTrevor Archer
Sep 19, 2007·Psychiatry and Clinical Neurosciences·Nobuyuki NiekawaOsamu Matsuda
Aug 25, 2007·Annual Review of Clinical Psychology·Philip D HarveyChristopher R Bowie
Aug 25, 2007·Annual Review of Clinical Psychology·Michael F Green
Jul 2, 2003·Psychosomatics·Jason E SchillerstromDonald R Royall
Jun 1, 2011·International Journal of Mental Health Systems·Marhani MidinAishvarya Sinniah
Dec 1, 2006·Neuropsychiatric Disease and Treatment·Christopher R Bowie, Philip D Harvey
Oct 22, 2013·Biological Psychiatry·Elçin AkdoganElisabeth Bacon
Jul 16, 2014·Psychiatry Research·Marie Izaute, Isabelle Jalenques

Citations

Dec 1, 1976·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·H E Nelson
Jan 1, 1992·Schizophrenia Bulletin·G E Hogarty, S Flesher
Jul 1, 1991·Archives of General Psychiatry·A J SaykinP Stafiniak
Dec 1, 1990·The British Journal of Psychiatry : the Journal of Mental Science·Til WykesR Katz
Jan 1, 1970·Acta Psychiatrica Scandinavica·U Malm
Jul 28, 1995·Psychiatry Research·Kim T MueserA S Bellack
Jan 1, 1995·Schizophrenia Bulletin·D L PennD Reed
Aug 1, 1994·Psychiatry Research·P W CorriganR Toomey
Jan 1, 1994·Schizophrenia Bulletin·R H BenedictR F Asarnow
Mar 1, 1996·The American Journal of Psychiatry·Michael F Green
Dec 1, 1995·Psychopharmacology·P M DingemansR M Smeets
May 3, 1997·Schizophrenia Research·D I VelliganA L Miller

Related Concepts

Individual Adjustment
Neurologic Manifestations
Schizophrenia
Chronic Disease
Memory for Designs Test
Outcomes Research
Mild Cognitive Disorder
Regression Analysis
Self Care (Rehabilitation)
Overinclusion

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Synapse Loss as Therapeutic Target in MS

As we age, the number of synapses present in the human brain starts to decline, but in neurodegenerative diseases this occurs at an accelerated rate. In MS, it has been shown that there is a reduction in synaptic density, which presents a potential target for treatment. Here is the latest research on synapse loss as a therapeutic target in MS.

Artificial Intelligence in Cardiac Imaging

Artificial intelligence (ai) techniques are increasingly applied to cardiovascular (cv) medicine in cardiac imaging analysis. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

Social Learning

Social learning involves learning new behaviors through observation, imitation and modeling. Follow this feed to stay up to date on the latest research.

Cell Atlas of the Human Eye

Constructing a cell atlas of the human eye will require transcriptomic and histologic analysis over the lifespan. This understanding will aid in the study of development and disease. Find the latest research pertaining to the Cell Atlas of the Human Eye here.

Single Cell Chromatin Profiling

Techniques like ATAC-seq and CUT&Tag have the potential to allow single cell profiling of chromatin accessibility, histones, and TFs. This will provide novel insight into cellular heterogeneity and cell states. Discover the latest research on single cell chromatin profiling here.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells.