Do splanchnic viscera contribute to liver preservation reperfusion injury?

Transplantation
H N SankaryJ Williams

Abstract

Preservation-reperfusion injury of hepatic allografts is thought to be associated with Kupffer cell activation and TNF release from the transplanted organ. Confirmation that the allograft is the source of this TNF in an in vivo model is difficult because of rapid equilibration of this cytokine into all compartments. A novel experimental design was devised to aid in accurate localization of the site of TNF release following a orthotopic liver transplant (OLT). In the first group (anhepatic), livers were removed from rats and splanchnic and systemic venous returns were then reestablished using a conduit of donor IVC and portal vein with a portasystemic shunt. In the second group (asplanchnic), the liver, stomach, pancreas, and intestine of the recipient were removed and a donor liver was reimplanted using the recipient IVC as the source of portal blood. The third (OLT-16) and fourth (OLT 8) groups underwent standard OLT with preservation times of 16 and 8 hr in 4 degrees C Euro-Collins solution, respectively. TNF levels were significantly increased in the OLT-16 group compared with the OLT-8 group. There were modest elevations of TNF in the anhepatic model, but the TNF in the asplanchnic model approached baseline. Absence of TNF ...Continue Reading

References

Aug 1, 1992·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·T IkedaK Sugimachi
Dec 1, 1991·Transplant International : Official Journal of the European Society for Organ Transplantation·I MarziR G Thurman
Jan 1, 1991·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J C Caldwell-KenkelJ J Lemasters
Jul 1, 1991·The Journal of Surgical Research·H N SankaryJ W Williams
Dec 1, 1989·Cryobiology·D C MarshJ H Southard
Sep 1, 1989·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J C Caldwell-KenkelJ J Lemasters
Jan 1, 1982·European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes·D CastaingH Bismuth
Aug 1, 1994·The Journal of Surgical Research·C E Scott-Conner, J B Grogan

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Citations

Jul 29, 2000·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·J K MaringM J Slooff
Apr 30, 1999·Transplantation·K J OldhaferR Pichlmayr
Oct 26, 1999·Transplantation·H N SankaryJ W Williams
May 22, 2013·Clinical & Developmental Immunology·Toshiaki NakanoShigeru Goto
Aug 27, 2013·The Journal of Surgical Research·Shi-Qi LiuGe Zhao

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