Do statins prevent Alzheimer's disease? A narrative review

European Journal of Internal Medicine
Homayoun L DaneschvarGerald W Smetana

Abstract

Alzheimer's disease is the most common cause of dementia and occurs commonly in patients 65 and older. There is an urgent need to find an effective management that could help prevent or at least slow down the progress of this major public health problem. Cholesterol related pathways might play a role in the pathogenesis of Alzheimer's disease. Treatment with 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors (statins) has been suggested to promote the prevention of Alzheimer's disease. In this review, we discuss potential pathogenetic pathways for the development of Alzheimer's disease and review the evidence regarding the value of statins as a strategy to prevent or delay progression of Alzheimer's disease.

References

May 29, 1998·Circulation·P W WilsonW B Kannel
May 30, 1998·Archives of Neurology·P GiannakopoulosC Bouras
Aug 25, 1999·Lancet·R S RosensonL C Casey
Sep 29, 1999·Proceedings of the National Academy of Sciences of the United States of America·M S Brown, J L Goldstein
Nov 23, 2000·Lancet·H JickD A Drachman
Sep 7, 2002·Stroke; a Journal of Cerebral Circulation·Donald R Royall
Nov 30, 2002·Lancet·James ShepherdUNKNOWN PROSPER study group. PROspective Study of Pravastatin in the Elderly at Risk
Feb 1, 2003·Trends in Pharmacological Sciences·Giuseppe CirinoWilliam C Sessa
Sep 10, 2003·Archives of Internal Medicine·Donald M Lloyd-JonesDaniel Levy
Feb 26, 2005·Stroke; a Journal of Cerebral Circulation·Philip B Gorelick
Dec 22, 2005·American Heart Journal·Peter A McCulloughUNKNOWN IEPR Investigators
Aug 12, 2008·Current Alzheimer Research·D Larry SparksCarolyn Liebsack
Oct 22, 2008·Journal of Neurology, Neurosurgery, and Psychiatry·M D M HaagM M B Breteler
Apr 17, 2012·Lancet·Hans J Markowitsch, Angelica Staniloiu
Jan 12, 2013·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Martin PrinceCleusa P Ferri
Oct 8, 2013·Mayo Clinic Proceedings·Kristopher J SwigerSeth S Martin

❮ Previous
Next ❯

Citations

Feb 23, 2017·Annual Review of Immunology·Marco Colonna, Oleg Butovsky
Mar 10, 2017·Neuroscience Letters·Fabricio Ferreira de OliveiraPaulo Henrique Ferreira Bertolucci
Jan 6, 2018·Journal of Personalized Medicine·Ramón CacabelosÓscar Teijido
Sep 28, 2018·Journal of Cellular Biochemistry·Neda ShakourAmirhossein Sahebkar
May 31, 2017·Translational Psychiatry·I K KarlssonS Hägg
Jan 14, 2020·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Kun XuanYehuan Sun
Aug 24, 2019·Current Alzheimer Research·Jessica Sarahi Alavez-Rubio, Teresa Juarez-Cedillo
Jul 1, 2017·JAD Reports·Md Rashidur RahmanMostakim Sharif
Apr 14, 2017·Canadian Pharmacists Journal : CPJ = Revue Des Pharmaciens Du Canada : RPC·Silvia DuongFeng Chang
Jun 5, 2017·Metabolic Brain Disease·Seyed Soheil Saeedi SaraviAhmad Reza Dehpour
Feb 9, 2017·Oxidative Medicine and Cellular Longevity·Giulia AbateDaniela Uberti
Dec 8, 2020·Alzheimer's & Dementia : Translational Research & Clinical Interventions·Georgina Torrandell-HaroRoberta Diaz Brinton
Dec 22, 2020·Nutrition and Healthy Aging·Sandeep Kumar, Timothy R Peterson
Mar 3, 2021·European Journal of Pharmacology·Tayebeh NooriSamira Shirooie

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood Coagulation Signaling Pathways

Coagulation is the process by which a blood clot is formed. This process includes both the formation of a platelet plug as well as a cascade of clotting factors resulting in the formation of fibrin strands. Find the latest research on coagulation signaling pathways here.

Atherosclerosis Disease Progression

Atherosclerosis is the buildup of plaque on artery walls, causing stenosis which can eventually lead to clinically apparent cardiovascular disease. Find the latest research on atherosclerosis disease progression here.

Alzheimer's Disease: APOE

Apolipoprotein E (APOE) polymorphic alleles are major genetic risk factors for Alzheimer's disease. Discover the latest research on APOE and other genetic determinants of Alzheimer's disease here.

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.

ApoE Phenotypes

Apolipoprotein E (APOE) is a protein involved in fat metabolism and associated with the pathogenesis of Alzheimer's disease and cardiovascular disease. Here is the latest research on APOE phenotypes.

Related Papers

BMJ : British Medical Journal
S Gottleib
European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies
C J LavieR V Milani
© 2021 Meta ULC. All rights reserved