PMID: 9660309Jul 11, 1998Paper

Do taste factors contribute to the mediation of ethanol intake? Ethanol and saccharin-quinine intake in three rat strains

Alcoholism, Clinical and Experimental Research
F L Goodwin, Z Amit

Abstract

Several recent studies have suggested that ethanol-preferring rodents may also have an affinity for sweet solutions (saccharin, sucrose) and, conversely, that saccharin preference may predict ethanol preference. The purpose of the present investigation was to determine whether intake of ethanol and saccharin-quinine (SQ) solutions would be related in three nonselected strains of rats who differ in their ethanol preference: Lewis, Wistar Kyoto, and Wistar. In the first phase of the experiment, all animals were presented with an ascending series of ethanol solutions (2 to 10%) in free choice with water, followed by a 10-day maintenance period of 10% ethanol with water. In the second phase, the same animals were presented with an ascending series of SQ solutions (saccharin: 0.4%, quinine: 0.001 to 0.04%) in free choice with water, followed by a 10-day maintenance period of 0.4% saccharin with 0.04% quinine and water. The results revealed an absence of a direct relationship between ethanol and SQ consumption. The ethanol-nonpreferring Lewis rats showed a greater preference for the SQ solutions than Wistar Kyoto rats, whereas the ethanol-preferring Wistar Kyoto strain consistently consumed significantly less SQ. Wistar rats showed r...Continue Reading

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Citations

Jun 23, 2001·Pharmacology, Biochemistry, and Behavior·M PallarèsN Ferré
Feb 23, 2000·Pharmacology, Biochemistry, and Behavior·F L GoodwinZ Amit
Mar 19, 2003·Behavioural Brain Research·Peter W MarinelliChristina Gianoulakis
Nov 5, 2010·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Susmita ChatterjeeSelena E Bartlett
Jun 7, 2014·Pharmacological Reports : PR·Wanda DyrPrzemysław Bieńkowski
Mar 3, 2007·Progress in Neuro-psychopharmacology & Biological Psychiatry·Elena Martin-GarcíaMarc Pallarès
Oct 6, 2005·Alcoholism, Clinical and Experimental Research·Elena Martin-Garcia, Marc Pallares
Jul 12, 2008·Alcoholism, Clinical and Experimental Research·Antoniette M MaldonadoCheryl L Kirstein
Apr 22, 2004·Pharmacology, Biochemistry, and Behavior·Sònia DarbraNuria Ferré

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