Do the binding properties of oligosaccharides in milk protect human infants from gastrointestinal bacteria?

The Journal of Nutrition
David S Newburg

Abstract

The oligosaccharide fraction of human milk, the third most abundant solid constituent, consists of hundreds of structures, many of them fucosylated. Oligosaccharides may bear structural homology to cell surface glycoconjugates used as receptors by pathogens, thus protecting nursing infants. The ability of human milk to protect against heat-stable enterotoxin of Escherichia coli in suckling mice has been attributed to neutral fucosylated oligosaccharides of milk. The same phenomenon has been found in human T84 cells, allowing the mechanism of inhibition by the oligosaccharide to be studied in vitro. The oligosaccharide binds to the extracellular domain of guanylyl cyclase, thereby inhibiting the binding of stable toxin. The protective oligosaccharide is a large structure present in too low a concentration to be routinely measured directly; however, its concentration in milk may be inferred by measuring smaller, more plentiful, structurally homologous oligosaccharides. The adhesion by invasive pathogenic strains of Campylobacter to their enterocyte target is also inhibited by human milk fucosyloligosaccharides. Because Campylobacter binds H-2 type oligosaccharide structures, the concentration of protective oligosaccharide may als...Continue Reading

References

Oct 1, 1990·Journal of Pediatric Gastroenterology and Nutrition·D VivergeM Solere
Dec 1, 1983·The Journal of Infectious Diseases·T G ClearyL K Pickering
Jul 1, 1996·Journal of Mammary Gland Biology and Neoplasia·D S Newburg

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Citations

Mar 4, 2000·Journal of Pediatric Gastroenterology and Nutrition·A BergerG Crozier
Mar 4, 2000·Journal of Pediatric Gastroenterology and Nutrition·C DananM J Butel
Jan 11, 2000·The Proceedings of the Nutrition Society·S M Filteau
Jul 20, 2007·The Proceedings of the Nutrition Society·Lars A Hanson
Jul 31, 2007·Breastfeeding Medicine : the Official Journal of the Academy of Breastfeeding Medicine·Mary Beth Flanders StepansDavid S Newburg
Jul 13, 2016·Gastroenterology Research and Practice·Ya-Ling ChenYi-Wen Chien
Jun 15, 2019·The British Journal of Nutrition·Andrea LeongHarsharn Gill
Nov 24, 1999·Acta Paediatrica. Supplement·G V CoppaO Gabrielli
Mar 18, 2000·The Journal of Nutrition·L C Duffy
Aug 30, 2005·Antimicrobial Agents and Chemotherapy·James L LeachPedro A Prieto
Oct 6, 2005·Journal of Pediatric Gastroenterology and Nutrition·Fabien MagneJehan-François Desjeux
Mar 22, 2007·European Journal of Clinical Nutrition·S AsakumaY Sanai
Nov 18, 2006·Applied Microbiology and Biotechnology·Seong-Goo ByunJin-Ho Seo
Nov 10, 2006·Critical Reviews in Food Science and Nutrition·Ali NasirpourStéphane Desobry
Sep 24, 2005·The Journal of Nutrition·Jenni HakkarainenCarina Tikkanen-Kaukanen
Dec 5, 2006·Biochemistry. Biokhimii︠a︡·N A KarataevaG A Nevinsky
May 22, 2007·Biochemistry. Biokhimii︠a︡·N A Karataeva, G A Nevinsky
Dec 2, 2011·Annual Review of Food Science and Technology·Maciej ChichlowskiDavid A Mills
Jun 21, 2013·The American Journal of Clinical Nutrition·Gilda GeorgiBernd Stahl
Aug 1, 2014·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·D MunblitJ O Warner
Jun 21, 2020·Nutrients·Mostafa AsadpoorSaskia Braber
May 29, 2000·The Proceedings of the Nutrition Society·P J ReedsJ B van Goudoever
Jan 25, 2008·Journal of Applied Microbiology·G T MacfarlaneS Macfarlane
Aug 11, 2001·American Journal of Veterinary Research·Y AdkinsB Lönnerdal
Jun 1, 2001·Journal of Dairy Science·M J MartínP Hueso
Sep 16, 2006·Glycobiology·Bing MaDiane E Taylor
May 25, 2013·Revista paulista de pediatria : orgão oficial da Sociedade de Pediatria de São Paulo·Valterlinda Alves de O QueirozHugo da Costa R Júnior
May 16, 2012·Advances in Nutrition·G Adrienne Weiss, Thierry Hennet
Dec 9, 2000·The Journal of Nutrition·M J GnothS Rudloff
Aug 7, 2010·Proceedings of the Japan Academy. Series B, Physical and Biological Sciences·Akira Kobata
Aug 12, 2018·Nutrients·Julio Plaza-DíazAngel Gil
Feb 2, 2010·Journal of Physiology and Biochemistry·M Sabater-MolinaS Zamora
Nov 17, 2016·Revista da Associação Médica Brasileira·Patricia Palmeira, Magda Carneiro-Sampaio
Feb 6, 2003·The British Journal of Nutrition·Wataru SumiyoshiKazumasa Kimura
Mar 12, 2008·Clinical Reviews in Allergy & Immunology·Carol L WagnerDonna Johnson

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