Do topical antibiotics provide improved prophylaxis against bacterial growth in the presence of polypropylene mesh?

American Journal of Surgery
M G TroyD Hecht

Abstract

Herniorrhaphies using a foreign body such as mesh can become infected. An experiment was performed in rabbits to compare three methods of antibiotic treatment to prevent the growth of bacteria in mesh-containing wounds. This experiment compared preoperative intravenous antibiotics (cefazolin), topical antibiotics applied intraoperatively (bacitracin), and their combination in preventing the quantitative growth of bacteria in a subcutaneous wound containing a polypropylene mesh inoculated with Staphylococcus aureus. The bacteria were inoculated in doses sufficient to deliberately cause the growth of 130.0 +/- 56.4 x 10(4) bacteria per gram of tissue in saline-treated control animals. Quantitative cultures of the mesh and surrounding tissues were obtained 5 days after insertion of the mesh and inoculation of the wound. Experimental data showed that treatment with systemic intravenous antibiotics, topical powdered antibiotics, or their combination all statistically significantly decreased the quantitative cultures grown from the inoculated tissues as compared with saline-treated controls (P<0.05). However, there were no statistically significant differences in quantitative growth among the three methods of antibiotic treatment. An...Continue Reading

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Citations

Dec 8, 2004·Surgical Endoscopy·A M CarbonellB T Heniford
Oct 26, 2005·Surgical Endoscopy·J E Losanoff, J M Millis
Feb 3, 2006·Hernia : the Journal of Hernias and Abdominal Wall Surgery·A G HarrellB T Heniford
Jun 20, 2013·Hernia : the Journal of Hernias and Abdominal Wall Surgery·D SandersJ A Steer
Dec 6, 2012·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Emmanuel E SadavaMichael J Rosen
Jul 31, 1998·American Journal of Surgery·D V MannA Darzi
Feb 3, 1999·The Surgical Clinics of North America·M Deysine
Feb 24, 2009·Journal of Neurosurgery·Jonathan P MillerKim J Burchiel
Mar 25, 2009·Cirugía española·Jose Bueno LledóJosé Mir Pallardó
Dec 15, 2015·Surgical Infections·Bárbara Pérez-KöhlerJuan Manuel Bellón
Mar 29, 2007·ANZ Journal of Surgery·Dilek KilicFatih Agalar
Jan 15, 2005·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·M E Falagas, S K Kasiakou
Aug 27, 2005·Acta chirurgica Iugoslavica·M ZuvelaI Palibrk

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