Do we alter ultraviolet sensitivity in vivo with stratum corneum rehydration? A pilot study and review of the literature

The British Journal of Dermatology
S C Behrens-WilliamsM Kerscher

Abstract

Numerous therapeutic schemes recommend topical administration of emollients immediately prior to ultraviolet (UV) B therapy. The rationale behind the clinical improvement is a presumed enhancement of UV transmission through the epidermis. Originating from this clinical observation, there has been some concern as to whether a well-hydrated skin in general might be more susceptible to actinic damage. To investigate whether rehydration of healthy skin causes an altered UVB sensitivity in vivo. We determined minimal erythema doses (MEDs) and erythema sum scores (ESSs) after differential rehydration of the skin in 10 healthy volunteers. In each subject six UVB phototests were performed after pretreatment with five different emulsifying ointments (unguentum emulsificans and dilutions with 30, 50, 70 and 90% aqua purificans) plus a negative control. In vivo evaluation of stratum corneum hydration was performed by measurement of electrical capacitance. The results of this randomized, double-blind in vivo study indicated that rehydration of normal stratum corneum with the emulsifying ointments tested did not result in a significantly altered sensitivity to the erythematous effects of UVB irradiation (no significant differences in MED an...Continue Reading

References

Aug 1, 1979·The Journal of Investigative Dermatology·M J Le VineJ A Parrish
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Jun 1, 1988·Archives of Dermatology·T B Fitzpatrick
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May 23, 1998·Current Problems in Dermatology·D C Salter
Oct 21, 1998·Photodermatology, Photoimmunology & Photomedicine·T Gambichler, F Schröpl

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Citations

May 25, 2006·Photodermatology, Photoimmunology & Photomedicine·Emel FetilAli Tahsin Güneş
Sep 22, 2012·International Journal of Cosmetic Science·A V Rawlings, K J Lombard
Feb 13, 2013·Journal of the American Academy of Dermatology·Manuela L AsztalosJohn Koo

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