Do we have to consider acidosis induced by exercise as deleterious in sickle cell disease?

Experimental Physiology
Benjamin ChatelDavid Bendahan


What is the topic of this review? The aim of this review is to discuss the potential involvement of exercise-induced acidosis in the commonly reported complications in sickle cell disease. What advances does it highlight? Blood acidosis appears clearly to be a risk factor for HbS polymerization, red blood cell sickling and the occurrence of vaso-occlusive crisis and could induce hyperkalaemia-related complications. It could be of great interest to try to avoid blood acidosis during exercise, which could be done using some alkalinizing solutions or adapted endurance training interventions. Sickle cell disease (SCD) is an inherited haemoglobin (Hb) disorder and the most common monogenic disease in the world. The root cause of this pathology is the synthesis of an abnormal Hb (HbS) that polymerizes in deoxygenated conditions, leading to the sickling of red blood cells. Acidosis is well recognized as a promoter of HbS polymerization and therefore red blood cell sickling. Indeed, it has been shown in vitro that the relative amount of sickled red blood cells increases markedly from 1% at pH 7.4 to >90% at pH 7.0. Nevertheless, no study has directly tested whether exercise-induced acidosis could favour SCD complications. Greater knowl...Continue Reading


Apr 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·B Magdoff-FairchildJ F Bertles
Dec 28, 1976·Pflügers Archiv : European journal of physiology·K SahlinE Hultman
Jan 1, 1978·Metabolism: Clinical and Experimental·L Jorfeldt, A Juhlin-Dannfelt
Dec 1, 1992·Canadian Journal of Physiology and Pharmacology·R S McKelvieG J Heigenhauser
Jun 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·D VitouxY Beuzard
Dec 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·J HofrichterWilliam A Eaton
Nov 5, 1973·Journal of Molecular Biology·R W Briehl, S Ewert
Feb 1, 1971·JAMA : the Journal of the American Medical Association·L Barreras, L W Diggs
Jan 1, 1972·Journal of Applied Physiology·J B Osnes, L Hermansen
Mar 1, 1972·Journal of Applied Physiology·L Hermansen, J B Osnes
Jan 1, 1980·Biophysical Journal·S A Berger, W S King
Mar 1, 1994·The Journal of Physiology·N K VøllestadO M Sejersted
Mar 1, 1993·The Journal of Physiology·J BangsboB Saltin
Mar 11, 1996·Brain Research·A H WaterfallC A Marsden
Sep 18, 1998·The Biological Bulletin·F I HárosiJ R Van Keuren
Aug 10, 2000·The Journal of Clinical Investigation·D K Kaul, R P Hebbel
Jun 1, 2002·Journal of Critical Care·Walter H ReinhartRoland Walter
May 1, 1955·The Journal of Clinical Investigation·M R BECKLAKEJ P SCHREVE
Sep 21, 2006·American Journal of Hematology·Hisham MoheebMahmoud S El-Sayed
Sep 18, 2007·The Journal of Experimental Biology·Pia Koldkjaer, Michael Berenbrink
Aug 1, 2008·Journal of Child and Adolescent Psychiatric Nursing : Official Publication of the Association of Child and Adolescent Psychiatric Nurses, Inc·Jamesetta A Newland
Oct 3, 2009·Blood·Luis A Verduzco, David G Nathan
Oct 13, 2009·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·George BuchananShalini Shenoy
Mar 24, 2010·Genetics and Molecular Research : GMR·G TintiC R B Domingos
Apr 7, 2010·Clinical Hemorheology and Microcirculation·Tamas AlexyT D Coates
Dec 7, 2010·Lancet·David C ReesMark T Gladwin
May 6, 2011·American Journal of Hematology·Erfan NurCURAMA Study Group
Oct 4, 2011·British Journal of Sports Medicine·Mike LoosemoreHugh Montgomery
Oct 8, 2011·Journal of the American Society of Nephrology : JASN·Peter S Aronson, Gerhard Giebisch
Dec 2, 2011·IUBMB Life·Erica N Chirico, Vincent Pialoux
Jul 16, 2013·Advances in Experimental Medicine and Biology·Anne RiemannOliver Thews
Nov 11, 2014·British Journal of Haematology·Emmanuelle CharrinCyril Martin
Nov 11, 2014·American Journal of Hematology·Camille FaesCyril Martin
Mar 31, 2015·Revista brasileira de hematologia e hemoterapia·Camila Tatiana ZanoniSara Teresinha Olalla Saad
Sep 6, 2015·Blood Reviews·Philippe ConnesSamir K Ballas
Dec 25, 2015·British Journal of Sports Medicine·Cyril MartinPhilippe Connes
Feb 19, 2017·Calcified Tissue International·Debbie Norring-AgerskovHenrik L Jørgensen
Apr 8, 2017·Blood·William A Eaton, H Franklin Bunn
Apr 20, 2017·The New England Journal of Medicine·Frédéric B PielDavid C Rees
Jun 10, 2017·Pediatric Blood & Cancer·Robert I LiemAlexis A Thompson
Jun 19, 2017·Blood Cells, Molecules & Diseases·Emmanuelle CharrinCyril Martin
Sep 8, 2017·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·David BendahanThomas Jue
Jan 13, 2018·European Journal of Applied Physiology·Brian S FergusonL Bruce Gladden
Apr 5, 2018·Cell Metabolism·George A Brooks


Mar 29, 2019·Medicine and Science in Sports and Exercise·Laurent A MessonnierLéonard Féasson
Jul 19, 2020·American Journal of Hematology·Angèle N MerletEXDRE collaborative study group
Dec 12, 2019·Clinical Journal of the American Society of Nephrology : CJASN·Maud CazenaveMarie Courbebaisse
Dec 4, 2020·Journal of Applied Physiology·Laurent A MessonnierLéonard Féasson
Aug 29, 2020·Haematologica·Laurent A MessonnierPablo Bartolucci

Related Concepts

Metabolic Acidosis
Anemia, Sickle Cell
Abnormal Red Blood Cell
Exercise, Isometric
Disease Management

Related Feeds

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.


Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.