What is the topic of this review? The aim of this review is to discuss the potential involvement of exercise-induced acidosis in the commonly reported complications in sickle cell disease. What advances does it highlight? Blood acidosis appears clearly to be a risk factor for HbS polymerization, red blood cell sickling and the occurrence of vaso-occlusive crisis and could induce hyperkalaemia-related complications. It could be of great interest to try to avoid blood acidosis during exercise, which could be done using some alkalinizing solutions or adapted endurance training interventions. Sickle cell disease (SCD) is an inherited haemoglobin (Hb) disorder and the most common monogenic disease in the world. The root cause of this pathology is the synthesis of an abnormal Hb (HbS) that polymerizes in deoxygenated conditions, leading to the sickling of red blood cells. Acidosis is well recognized as a promoter of HbS polymerization and therefore red blood cell sickling. Indeed, it has been shown in vitro that the relative amount of sickled red blood cells increases markedly from 1% at pH 7.4 to >90% at pH 7.0. Nevertheless, no study has directly tested whether exercise-induced acidosis could favour SCD complications. Greater knowl...Continue Reading
Lactate and potassium fluxes from human skeletal muscle during and after intense, dynamic, knee extensor exercise
Inhibition of K+ efflux and dehydration of sickle cells by [(dihydroindenyl)oxy]alkanoic acid: an inhibitor of the K+ Cl- cotransport system
Kinetics and mechanism of deoxyhemoglobin S gelation: a new approach to understanding sickle cell disease
Cardio-pulmonary responses and gas exchange during exercise in adults with homozygous sickle-cell disease (sickle-cell anaemia)
Mobilization, collection, and processing of peripheral blood stem cells in individuals with sickle cell trait.
Studies on the destruction of red blood cells. XII. Factors influencing the role of S hemoglobin in the pathologic physiology of sickle cell anemia and related disorders
Studies on the destruction of red blood cells. XIII. Observations on the role of pH in the pathogenesis and treatment of painful crisis in sickle-cell disease
Alkalosis increases muscle K+ release, but lowers plasma [K+] and delays fatigue during dynamic forearm exercise
Physical fitness indices and anthropometrics profiles in schoolchildren with sickle cell trait/disease
Using serial haemorheological parameters to assess clinical status in sickle cell anaemia patients in vaso-occlussive crisis
Lactic acidosis in vivo: testing the link between lactate generation and H+ accumulation in ischemic mouse muscle
Oxidative stress in sickle cell disease; pathophysiology and potential implications for disease management
Frequency of pain crises in sickle cell anemia and its relationship with the sympatho-vagal balance, blood viscosity and inflammation
Hemorheological risk factors of acute chest syndrome and painful vaso-occlusive crisis in children with sickle cell disease
Pilot randomized controlled trial to evaluate the effect of aquatic and land physical therapy on musculoskeletal dysfunction of sickle cell disease patients
The Role of Inspiratory Muscle Training in Sickle Cell Anemia Related Pulmonary Damage due to Recurrent Acute Chest Syndrome Attacks
Perturbation of Akt Signaling, Mitochondrial Potential, and ADP/ATP Ratio in Acidosis-Challenged Rat Cortical Astrocytes
Moderate and intense muscular exercises induce marked intramyocellular metabolic acidosis in sickle cell disease mice
Comparative NMR and NIRS analysis of oxygen-dependent metabolism in exercising finger flexor muscles
Endurance training reduces exercise-induced acidosis and improves muscle function in a mouse model of sickle cell disease
Ischaemia-induced muscle metabolic abnormalities are poorly alleviated by endurance training in a mouse model of sickle cell disease
Changes in Oxidative Stress, Inflammation, and Muscle Damage Markers Following Diet and Beetroot Juice Supplementation in Elite Fencers
Muscle structural, energetic and functional benefits of endurance exercise training in sickle cell disease
In vivo muscle function and energetics in women with sickle cell anemia or trait: a 31P-magnetic resonance spectroscopy study.
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