Do we know how to diagnose epilepsy early in Alzheimer's disease?

Revue neurologique
Benjamin CretinFrederic Blanc

Abstract

Epilepsy is an increasingly recognized comorbidity in Alzheimer's disease (AD). First described as generalized in dementia patients, epileptic AD patients are nowadays fully described in earlier stages of the disease (with mild or subjective cognitive impairment). At such early stages, patients may present not only with generalized seizures, but also with focal seizures (commonly localized in the frontal or temporal lobe). Thus, partial or generalized epilepsy is part of the semiological spectrum of AD that should be borne in mind at all stages of disease to ensure early identification and prevent the risk of repeated seizures (such as accidents, injury, progression of cognitive impairment). This review of the available (and still growing) literature shows that there are already sufficient data to inform physicians on seizure semiology, and on the diagnostic value of electroencephalography and brain imaging. Taken together, these tools can help to rapidly identify epilepsy in AD patients. Nevertheless, epilepsy diagnosis can be challenging, and test medication is sometimes necessary. Some cerebrospinal fluid biomarkers (or their ratios) may also prove to be good predictors of seizures in AD, but further studies are needed. Epil...Continue Reading

Citations

Oct 27, 2017·Frontiers in Molecular Neuroscience·Denis SarrouilheMarc Mesnil
Jun 30, 2019·Frontiers in Neurology·Yusuke HirokawaTohru Okanishi
Jun 27, 2019·Expert Review of Neurotherapeutics·Graham PowellA J Larner
Dec 24, 2019·Frontiers in Neurology·John BakerAdam Zeman
Jun 19, 2020·Computational Intelligence and Neuroscience·Yvonne HöllerEugen Trinka
Sep 22, 2020·Neural Plasticity·Siddhartha Mondragón-RodríguezFernando Peña-Ortega
Jul 17, 2018·Expert Opinion on Pharmacotherapy·Benjamin Cretin
Dec 15, 2020·Drugs & Aging·Benjamin Cretin
Jan 15, 2021·Mechanisms of Ageing and Development·Claudio LiguoriCinzia Costa
Mar 9, 2020·Revue neurologique·J Dumurgier, C Tzourio
Apr 26, 2020·Revue neurologique·L ValtonJ Curot

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