PMID: 8585085Sep 1, 1995Paper

Do we know the complete sequence of metalloproteinase and nonenzymatic platelet aggregation inhibitor (disintegrin) precursor proteins?

Toxicon : Official Journal of the International Society on Toxinology
R M Kini

Abstract

Recent evidence indicates that metalloproteinases and disintegrins, nonenzymatic inhibitors of platelet aggregation, are derived by proteolysis from common precursors. Although proteins and polypeptides with various domain structures have been identified, proteins containing proprotein domains or the complete mature precursors have not yet been isolated. This prompted a closer examination of the putative start codon, signal peptide and the segment upstream of these regions. A critical evaluation of sequence information of these precursors indicates that the putative signal peptide identified in these precursors may be an internal hydrophobic segment within the precursor. There is also evidence to indicate that C-type lectin-related proteins are also derived from these precursors. Thus the available sequence data of the precursors appear to be incomplete.

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Citations

Nov 1, 1996·Toxicon : Official Journal of the International Society on Toxinology·R M Kini
Apr 1, 1997·Toxicon : Official Journal of the International Society on Toxinology·R M KiniB K Tan
Jul 22, 1999·Toxicon : Official Journal of the International Society on Toxinology·H C CastroR B Zingali
Mar 20, 1999·Biochimica Et Biophysica Acta·B R JenningsE G Shephard
Aug 6, 2011·Molecular Biology and Evolution·Emily S W WongKatherine Belov
Jul 12, 2005·Biological Chemistry·Jeanne Claíne de Albuquerque ModestoAna Marisa Chudzinski-Tavassi
Mar 5, 1999·Critical Reviews in Toxicology·R HatiK K Bhattacharyya

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