PMID: 8970015Jun 1, 1996Paper

Do we need full compliance data for population pharmacokinetic analysis?

Journal of Pharmacokinetics and Biopharmaceutics
P GirardT F Blaschke

Abstract

For population pharmacokinetic analysis of multiple oral doses one of the key issues is knowing as precisely as possible the dose inputs in order to fit a model to the input-output (dose-concentration) relationship. Recently developed electronic monitoring devices, placed on pill containers, permit precise records to be obtained over months, of the time/date opening of the container. Such records are reported to be the most reliable measurement of drug taking behavior for ambulatory patients. To investigate strategies for using and summarizing this new abundant information, a Markov chain process model was developed, that simulates compliance data from real data from electronically monitored patients, and data simulations and analyses were conducted. Results indicate that traditional population pharmacokinetic analysis methods that ignore actual dosing information tend to estimate biased clearance and volume and markedly overestimate random interindividual variability. The best dosing information summarization strategies consist of initially estimating population pharmacokinetic parameters, using no covariates and only a limited number of dose records, the latter chosen based on an a priori estimate of the half-life of the drug...Continue Reading

References

Oct 1, 1992·Journal of Pharmacokinetics and Biopharmaceutics·M Davidian, A R Gallant
Jan 1, 1991·European Journal of Clinical Pharmacology·R Vander Stichele
Aug 1, 1990·Journal of Pharmacokinetics and Biopharmaceutics·M K al-BannaB Whiting
Jun 1, 1986·Clinical Pharmacology and Therapeutics·T H GraselaR B Smith
Jun 1, 1994·Clinical Pharmacology and Therapeutics·M O Karlsson, L B Sheiner
Sep 1, 1993·Computer Methods and Programs in Biomedicine·L Aarons
Sep 1, 1993·Clinical Pharmacology and Therapeutics·G Levy
Jun 1, 1993·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·D M WaterhouseD E Brenner

❮ Previous
Next ❯

Citations

Jun 26, 2001·European Journal of Drug Metabolism and Pharmacokinetics·E O FadiranE I Ette
Feb 27, 2008·Journal of Pharmacokinetics and Pharmacodynamics·Pankaj GuptaRaymond Miller
Mar 30, 2011·Journal of Pharmacokinetics and Pharmacodynamics·Olivier BarrièreFahima Nekka
Dec 6, 2001·Current Hypertension Reports·J Urquhart
Oct 24, 2000·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·S H IngwersenL Aarons
Mar 22, 2013·BMC Medical Informatics and Decision Making·Erwin C VasbinderUNKNOWN e-MATIC Study Group
Dec 16, 2005·The AAPS Journal·Jerry R Nedelman
Dec 16, 2005·The AAPS Journal·Leslie A KennaMarc Pfister
Jun 22, 2014·Journal of Pharmacokinetics and Pharmacodynamics·Leonid GibianskyFranziska Schaedeli Stark
Sep 8, 2012·European Journal of Clinical Pharmacology·Erwin VasbinderPatricia van den Bemt
Jun 2, 2012·International Journal of Medical Informatics·M VervloetD H de Bakker
Nov 26, 2015·AIDS and Behavior·I Marion de Sumari-de BoerGibson S Kibiki
May 9, 2015·The Journal of Clinical Hypertension·Abida SolomonDejian Lai
Mar 21, 2006·Drug Metabolism and Pharmacokinetics·Takahiko TanigawaShun Higuchi
May 30, 2006·The Pediatric Infectious Disease Journal·Kristel M L CrommentuynJos H Beijnen
Mar 1, 2005·Basic & Clinical Pharmacology & Toxicology·Bernard VrijensJohn Urquhart
Mar 1, 2005·Basic & Clinical Pharmacology & Toxicology·Pascal Girard
Dec 12, 2018·CPT: Pharmacometrics & Systems Pharmacology·Yuhuan Wang, Xiaoxi Liu
Mar 14, 2008·Clinical Pharmacokinetics·Michel TodGérard Pons
Nov 12, 2005·Journal of Pharmacokinetics and Pharmacodynamics·Goonaseelan Colin PillaiJean-Louis Steimer
May 25, 2005·Clinical Pharmacokinetics·Jeffrey S BarrettMarc Pfister
Apr 18, 2014·Clinical Pharmacology and Therapeutics·B Vrijens, J Urquhart
Jan 15, 2000·Statistical Methods in Medical Research·B Vrijens, E Goetghebeur
Nov 17, 2020·AIDS Research and Human Retroviruses·Mustafa E IbrahimPeter L Anderson
Jan 1, 1997·Annual Review of Pharmacology and Toxicology·H Kastrissios, T F Blaschke

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.