Do we need new antibiotics for treating exacerbations of COPD?

Therapeutic Advances in Respiratory Disease
Marc Miravitlles

Abstract

Exacerbations may produce permanent impairment in lung function and health status in patients with COPD. Up to 70% of episodes have a bacterial etiology, being of mixed viral infection in some cases. The new, more active antibiotics have demonstrated better eradication of bacteria in the airways and, consequently, prolongation of the time to the next exacerbation. However, the ability of bacteria to develop resistance to the antibiotics currently used warrants novel research into new families of antimicrobials, and the adoption of new strategies such as the prevention of exacerbations, nebulized antibiotic treatment or the use of antibiotics in combination.

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Citations

Mar 23, 2012·Current Infectious Disease Reports·Salvador SialerAntoni Torres
Apr 23, 2013·Clinical Drug Investigation·Heino StassSybille Baumann
May 14, 2009·International Journal of Chronic Obstructive Pulmonary Disease·Carl LlorUNKNOWN BRAMOX Study Group
Jun 14, 2013·International Journal of Clinical Practice·E OzyilmazT Tatlicioglu
Jun 24, 2008·Expert Opinion on Pharmacotherapy·Marc Miravitlles, Antonio Anzueto
Jun 29, 2010·Respiratory Medicine·Antonio Anzueto, Marc Miravitlles
Nov 3, 2009·Therapeutic Advances in Respiratory Disease·Marc MiravitllesKathrin Stauch
Apr 12, 2013·Expert Review of Respiratory Medicine·Juan Antonio Trigueros Carrero
May 19, 2010·Expert Review of Respiratory Medicine·Timothy E Albertson, Andrew L Chan

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