Do we need new high-risk criteria for surgically treated renal cancer patients to improve the outcome of future clinical trials in the adjuvant setting? Results of a comprehensive analysis based on the multicenter CORONA database

European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
I WolffMembers of the CORONA Project and the European Association of Urology (EAU) Young Academic Urologists (YAU) Renal Cancer Gro

Abstract

Since there is still an unmet need for potent adjuvant strategies for renal cancer patients with high progression risk after surgery, several targeted therapies are currently evaluated in this setting. We analyzed whether inclusion criteria of contemporary trials (ARISER, ASSURE, SORCE, EVEREST, PROTECT, S-TRAC, ATLAS) correctly identify high-risk patients. The study group comprised 8873 patients of the international CORONA-database after surgery for non-metastatic renal cancer without any adjuvant treatment. Patients were divided into potentially eligible high-risk and assumable low-risk patients who didn't meet inclusion criteria of contemporary adjuvant clinical trials. The ability of various inclusion criteria for disease-free survival (DFS) prediction was evaluated by Harrell's c-index. During a median follow-up of 53 months 15.2% of patients experienced recurrence (5-year-DFS 84%). By application of trial inclusion criteria, 24% (S-TRAC) to 47% (SORCE) of patients would have been eligible for enrollment. Actual recurrence rates of eligible patients ranged between 29% (SORCE) and 37% (S-TRAC) opposed to <10% in excluded patients. Highest Hazard Ratio for selection criteria was proven for the SORCE-trial (HR 6.42; p < 0.001...Continue Reading

References

Oct 1, 1982·The American Journal of Surgical Pathology·S A FuhrmanC Limas
Apr 10, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Pierre I KarakiewiczJean-Jacques Patard
Oct 20, 2009·The Journal of Urology·Pierre I KarakiewiczJean-Jacques Patard
Jun 18, 2010·Expert Review of Anticancer Therapy·Sabine Brookman-MayMaximilian Burger
May 12, 2012·European Urology·Malek MeskawiPierre I Karakiewicz
Aug 27, 2013·Seminars in Oncology·Tobias JanowitzTim Eisen
Jun 28, 2014·The Oncologist·Sumanta K Pal, Naomi B Haas
Jan 27, 2015·European Urology·Borje LjungbergAxel Bex

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Citations

Mar 10, 2017·Nature Reviews. Disease Primers·James J HsiehVincenzo Ficarra
Aug 29, 2018·International Journal of Molecular Sciences·Hyeong Su KimDae Young Zang
May 10, 2020·Cell Death & Disease·Yangyang YueJinhai Fan
Dec 11, 2020·OncoTargets and Therapy·Eliana M C TacconiAndrew Protheroe

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