Do We Try Mending Humpty Dumpty or Prevent His Fall? An Alzheimer's Disease Dilemma

Journal of Alzheimer's Disease : JAD
C de la Torre Jack

Abstract

In the popular nursery rhyme, Humpty Dumpty's great fall and the inability to put him together again has been used to demonstrate the second law of thermodynamics. An oversimplification of this law states that all things in the universe tend to move from order to disorder, an occurrence that can be applied allegorically to the development and clinical outcome of Alzheimer's disease (AD). An important argument relevant to the future use of resources and primary focus of AD research arises from the question, do we make it a priority to mend the shattered brain of AD patients or attempt to prevent the brain from shattering? If the former approach continues to be the priority it has become, how exactly do we mend the irreparable neuronal loss and associated cognitive failure in advanced cases of AD? Or, must we change direction and make prevention the primary goal of AD research? The latter approach would identify asymptomatic or mildly symptomatic patients with high risk of developing dementia by means of establishing multidisciplinary heart-brain clinics that would provide either close observation or a tailored therapeutic intervention. This is an important challenge that needs to be achieved if the AD incidence, societal costs a...Continue Reading

References

Jan 1, 1991·Annals of the New York Academy of Sciences·S Hoyer
Jan 1, 1987·International Journal of Aging & Human Development·A La Rue, L F Jarvik
Feb 28, 1997·Neuroscience Letters·J C de la TorreF Gonzalez-Lima
Mar 11, 1999·Annals of Neurology·J L Price, J C Morris
Apr 28, 1999·Journal of Neuropathology and Experimental Neurology·D G DavisW R Markesbery
Mar 5, 2005·European Journal of Nuclear Medicine and Molecular Imaging·Lisa Mosconi
May 10, 2006·Archives of Neurology·Liana G ApostolovaPaul M Thompson
Sep 2, 2006·Neurological Research·Jack C de la Torre
Jan 16, 2007·Neurobiology of Aging·Lisa MosconiMony J de Leon
Mar 7, 2008·Neuro-degenerative Diseases·Jack C de la Torre
Sep 5, 2008·Neural Plasticity·Cathrin B CantoMenno P Witter
Nov 13, 2008·Archives of Neurology·Howard Jay AizensteinWilliam E Klunk
Oct 9, 2009·Alzheimer Disease and Associated Disorders·Linda L ChaoJulene K Johnson
Feb 26, 2010·Journal of Alzheimer's Disease : JAD·Jack C de la Torre
Feb 26, 2010·Journal of Alzheimer's Disease : JAD·Lisa MosconiMony J de Leon
Apr 14, 2010·Ageing Research Reviews·Jack C de la Torre
Jun 16, 2010·Annals of Internal Medicine·Brenda L PlassmanSophiya Benjamin
Mar 11, 2011·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Alex E RoherThomas G Beach
Jul 31, 2012·Journal of Alzheimer's Disease : JAD·Anna-Maija TolppanenMiia Kivipelto
Dec 25, 2012·Neuron·David R EustonBruce L McNaughton
Feb 28, 2013·Frontiers in Neural Circuits·Carmen Vivar, Henriette van Praag
Jul 3, 2013·American Journal of Alzheimer's Disease and Other Dementias·Jack C de la Torre
Aug 2, 2013·The New England Journal of Medicine·Michael D HurdKenneth M Langa
Aug 2, 2013·The New England Journal of Medicine·Zhou YangAllan Levey
Jan 24, 2014·The New England Journal of Medicine·Rachelle S DoodyUNKNOWN Solanezumab Study Group
Jan 24, 2014·The New England Journal of Medicine·Stephen SallowayUNKNOWN Bapineuzumab 301 and 302 Clinical Trial Investigators
Mar 5, 2014·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·David A Drachman
Mar 13, 2014·Revue neurologique·N B BolshetteR Gogoi
Mar 19, 2014·Acta Clinica Belgica·S EngelborghsM Vandewoude
Apr 2, 2014·International Psychogeriatrics·Latha VelayudhanGill Livingston
Jul 16, 2014·Alzheimer's Research & Therapy·Jeffrey L CummingsKate Zhong
Aug 7, 2014·Journal of Alzheimer's Disease : JAD·Jing ZhouLan Tan
Aug 13, 2014·Journal of Alzheimer's Disease : JAD·Jack C de la Torre
Sep 3, 2014·BMC Neurology·Michael A CastelloSalvador Soriano
Oct 10, 2014·Dementia and Geriatric Cognitive Disorders Extra·Nilton CustodioPatricia Cortijo

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