PMID: 7214944Apr 1, 1981Paper

Dobutamine: a hemodynamic evaluation in human septic shock

Critical Care Medicine
F JardinA Margairaz


The hemodynamic effect of dobutamine infusion (DI) was studied in 19 patients with septic shock. DI resulted in hemodynamic improvement as indicated by a significant increase in cardiac index (+36%, p less than 0.001), stroke index (+15%, p less than 0.01), mean arterial pressure (+20%, p less than 0.01), and a significant decrease in aVDO2 (-27%, p less than 0.01). This hemodynamic improvement occurred concomitantly with a fall in both right and left filling pressures. Mean systemic arterial resistance remained unchanged with a scatter of individual responses depending on other factors, such as infusion rate, initial vascular resistance, and underlying hemodynamic setting. In patients mechanically ventilated, venous admixture in the lung (Qs/Qt) during DI increased significantly (+30%, p less than 0.001) and insignificantly reduced PaO2, but this adverse effect was not observed when PEEP was used in patients mechanically ventilated. It is concluded that dobutamine can be useful in management of septic shock, particularly when filling pressures are high because of fluid overload or cardiac failure.


Sep 18, 1997·Nutrition·R ChioléroL Tappy
Feb 1, 1991·Acta Anaesthesiologica Scandinavica·P Van der LindenJ L Vincent
Dec 14, 2006·Critical Care : the Official Journal of the Critical Care Forum·Sergio L Zanotti Cavazzoni, R Phillip Dellinger
Jun 15, 1988·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·M Mikkelsen
Jan 1, 1984·Nutrition and Health·C M Reading

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