Dobutamine enhances cardiodepressant effects of receptor-mediated coronary endothelial stimulation

Circulation
J BartunekW J Paulus

Abstract

In humans, intracoronary infusion of substance P reduces left ventricular end-systolic pressure and left ventricular peak systolic pressure because of earlier onset of left ventricular relaxation induced by paracrine myocardial action of mediators released from the coronary endothelium. The present study investigated in humans the effects of beta-adrenergic stimulation, which also induces earlier left ventricular relaxation, on the left ventricular myocardial contractile response to intracoronary infusion of substance P. Data were obtained in 13 patients after cardiac transplantation and in 3 patients with dilated nonischemic cardiomyopathy. Microtip left ventricular pressure recordings were obtained during a 5-minute intracoronary infusion of substance P (20 pmol/min) under control conditions and then repeated during concurrent intravenous administration of dobutamine. In the presence of dobutamine, intracoronary substance P caused a greater fall in left ventricular end-systolic pressure (transplantation control, -9 +/- 11 versus transplantation dobutamine, -20 +/- 18 mm Hg [P < .05]; cardiomyopathy control, -4 +/- 1 versus cardiomyopathy dobutamine, -10 +/- 3 mm Hg [P < .05]) and in left ventricular peak systolic pressure (tr...Continue Reading

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Citations

Jun 14, 2005·Pharmacology & Therapeutics·R SchulzJ-L Balligand
Apr 13, 2000·Pharmacology & Therapeutics·A M Shah, P A MacCarthy
May 1, 1997·Journal of the American College of Cardiology·W J PaulusH Drexler
Feb 26, 2000·European Journal of Clinical Investigation·B de ValkJ J Marx
Jan 24, 2002·Current Opinion in Critical Care·P B MassionJ L Balligand
May 10, 2002·Circulation Journal : Official Journal of the Japanese Circulation Society·Yuji HamamichiToshio Miyawaki
Feb 8, 2002·Clinical Chemistry and Laboratory Medicine : CCLM·J WhicherL M Biasucci
Jun 3, 1998·Intensive Care Medicine·R M Grocott-Mason, A M Shah
Jun 18, 2004·Journal of Hypertension·Naohiko KobayashiHiroaki Matsuoka
Oct 1, 1998·Journal of Cardiac Failure·M A Arstall, R A Kelly
Dec 19, 2001·American Journal of Physiology. Heart and Circulatory Physiology·A PiechJ-L Balligand
Jul 12, 2003·American Journal of Physiology. Heart and Circulatory Physiology·David A WinkNazareno Paolocci
Nov 16, 2001·American Journal of Physiology. Heart and Circulatory Physiology·H PostG Heusch

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