Dobutamine improves liver function after hemorrhagic shock through induction of heme oxygenase-1

American Journal of Respiratory and Critical Care Medicine
Alexander RaddatzHauke Rensing

Abstract

Induction of heme oxygenase-1 (HO-1) protects the liver against reperfusion injury after hemorrhagic shock. Previous data suggest that the beta(1)-adrenoceptor agonist dobutamine induces HO-1 in hepatocytes. To investigate the functional significance of dobutamine pretreatment for liver function after hemorrhagic shock in vivo. Anesthetized rats received either Ringer's (Vehicle/Shock), 10 microg/kg/min of the beta(1)-adrenoceptor agonist dobutamine (Dob/Shock), or 10 microg/kg/min dobutamine and 500 microg/kg/min of the beta(1)-adrenoceptor antagonist esmolol (Dob/Esmolol/Shock) for 6 h. Hemorrhagic shock was induced thereafter (mean arterial pressure, 35 mm Hg for 90 min). Animals were resuscitated with shed blood and Ringer's. In addition, the HO pathway was blocked after dobutamine pretreatment with 10 micromol/kg tin-mesoporphyrin-IX (Dob/SnMP/Shock) or animals received 100 mg/kg of the carbon monoxide donor dichloromethane (DCM/Shock). Hepatocellular metabolism and liver blood flow were measured by plasma disappearance rate of indocyanine green (PDR(ICG)) as a sensitive marker of liver function. Pretreatment with dobutamine induced HO-1 in pericentral hepatocytes and improved PDR(ICG) (Vehicle/Shock: 11.7 +/- 8.12%/min vs...Continue Reading

References

Mar 1, 1992·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A KooN Kaplowitz
Apr 1, 1987·Journal of Applied Physiology·G M MatuschakR M Rogers
Feb 1, 1987·Clinical Physiology·I L Kanstrup, K Winkler
Dec 9, 1983·European Journal of Pharmacology·N G MorganJ H Exton
Sep 1, 1983·The Journal of Trauma·M E GottliebD M Shah
Nov 1, 1995·The Journal of Clinical Investigation·M SuematsuY Ishimura
Aug 1, 1994·American Journal of Respiratory and Critical Care Medicine·G GutierrezC Nelson
Jul 1, 1996·American Journal of Respiratory Cell and Molecular Biology·A M Choi, J Alam
Dec 1, 1996·American Journal of Respiratory and Critical Care Medicine·R NevièreF Wattel
Jul 15, 1997·European Journal of Biochemistry·W K McCoubreyM D Maines
Mar 21, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·I BauerM Bauer
May 1, 1998·American Journal of Respiratory and Critical Care Medicine·D De BackerJ L Vincent
Dec 10, 1999·The Journal of Clinical Investigation·F AmersiJ W Kupiec-Weglinski
Dec 10, 1999·American Journal of Respiratory and Critical Care Medicine·L M JolyJ F Dhainaut
Mar 27, 2001·Gastroenterology·R A Weisiger
Nov 3, 2001·Journal of Hepatology·J M MatoM A Avila
Dec 26, 2001·Archives of Surgery·C D RaeburnA H Harken
May 1, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Claudio A RedaelliJean-François Dufour
Oct 24, 2002·Transplantation·Masamichi KatoriJerzy W Kupiec-Weglinski
Oct 1, 1958·Proceedings of the Society for Experimental Biology and Medicine·H O WHEELERJ I MELTZER

❮ Previous
Next ❯

Citations

Jan 1, 2013·Journal of Anesthesia·Iosifina I KarmaniolouNikolaos F Arkadopoulos
Aug 2, 2007·Critical Care Medicine·Hauke Rensing
Mar 27, 2007·American Journal of Respiratory and Critical Care Medicine·Eric B MilbrandtDerek C Angus
Jan 30, 2009·Journal of Clinical Biochemistry and Nutrition·Toru TakahashiKiyoshi Morita
Nov 15, 2007·Nitric Oxide : Biology and Chemistry·Alexander HoetzelBenedikt H J Pannen
May 21, 2013·Journal of Critical Care·Amal Rashad ReyadNadia A Hasaneen
Oct 1, 2012·Hepatology International·Goolab TrilokXu Li-Jun
Mar 8, 2008·Pharmacological Reviews·Nader G Abraham, Attallah Kappas

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adrenergic Receptors: Trafficking

Adrenergic receptor trafficking is an active physiological process where adrenergic receptors are relocated from one region of the cell to another or from one type of cell to another. Discover the latest research on adrenergic receptor trafficking here.

American Thoracic Association Journals

Discover the latest respiratory research published by the journals from the American Thoracic Society.