Dobutamine stress echocardiography identifies anthracycline cardiotoxicity

European Journal of Echocardiography : the Journal of the Working Group on Echocardiography of the European Society of Cardiology
Y CottinJ E Wolf

Abstract

Anthracyclines are effective anti-cancer agents, but their therapeutic value is limited by their myocardial toxicity. We assessed the physiological responses of stress echocardiography at low doses of dobutamine (DSE) in patients treated with anthracycline. In a prospective study, 28 patients were studied before and 1 month after the end of chemotherapy. All patients had normal ejection fraction (EF) at rest before therapy and the mean dose of anthracycline was 212+/-15 mg/m(2). Echocardiographic Doppler studies were performed before and during dobutamine infusion (5 and 10 microg/kg per min). Rest echocardiography demonstrated a significant decrease of EF between the two examinations in ejection fraction (67+/-3% vs. 61+/-3%, P<0.001). The increase of the EF during dobutamine infusion was higher after chemotherapy compared to the initial examination (19+/-3% vs. 29+/-3%: P<.05). No difference in EF was observed at 10 microg/kg per min between before and after chemotherapy. In contrast, at rest no difference in diastolic parameters was observed between the two examinations. Moreover, a significant decrease of the peak E and the ratio E/A was observed during dobutamine infusion after chemotherapy (93+/-4 cm/s vs. 79+/-5 cm/s and...Continue Reading

Citations

Feb 22, 2012·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Ronny S JijiMichael Salerno
Sep 29, 2005·Archives of Disease in Childhood·E De CaroR Haupt
Jan 27, 2007·Cardiovascular Ultrasound·Maurizio GalderisiOreste de Divitiis
Jun 8, 2013·The International Journal of Cardiovascular Imaging·Mohamed AissiouDaniel Curnier
Nov 9, 2010·Pediatric Blood & Cancer·Enrico De CaroGiacomo Pongiglione
Sep 20, 2011·European Heart Journal Cardiovascular Imaging·Hirohiko MotokiUichi Ikeda
Jun 5, 2012·Cardiovascular Toxicology·Paolo Della PinaLivio Dei Cas
Dec 5, 2020·BioMed Research International·Jayasinghe Arachchige Nirosha SandamaliJayamini Horadugoda

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