Dobutamine stress echocardiography

European Heart Journal
W KrahwinkelH Gülker

Abstract

Dobutamine is a synthetic catecholamine with predominant beta-stimulation. Its half-life is approximately 2 min. The positive chronotropic and inotropic effects of dobutamine induce myocardial ischaemia if significant coronary artery obstruction is present. Regional ischaemia produces regional wall motion abnormalities which can be detected by echocardiography. Most dobutamine stress protocols start at an infusion rate of 5 micrograms.kg-1.min-1 and increase to a peak dose of 40 or 50 micrograms.kg-1.min-1; to further increase heart rate, a bolus injection of 0.25-1.0 mg atropine is added. Test endpoints are the detection of new wall motion abnormalities, the occurrence of severe complications or achievement of the target heart rate. Viable myocardial regions have a positive inotropic reserve, which can be stimulated by dobutamine and detected by echocardiography. Indications for the use of dobutamine stress echocardiography are to prove stress-inducible myocardial ischaemia and to detect myocardial viability. The test should only be performed for the detection of stress-induced myocardial ischaemia if patients are unable to undergo exercise echocardiography, or if patients fail to reach their required test level in exercise ec...Continue Reading

Citations

Aug 23, 2001·Ultrasound in Medicine & Biology·G JacobA P Banning
Oct 28, 2005·Cardiovascular Ultrasound·Eric PlanteMarie Arsenault
May 21, 1998·Herz·M Elsner
Dec 6, 2011·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Wojciech RudzinskiMarc Klapholz
Feb 10, 2016·PloS One·Jennifer M PetrosinoOuliana Ziouzenkova
Oct 5, 2019·Clinical Kidney Journal·Federica E PoliMatthew P Graham-Brown
Oct 30, 2016·Annals of the Royal College of Surgeons of England·Jml Williamson, D Mahon
Dec 17, 2019·American Journal of Physiology. Gastrointestinal and Liver Physiology·Mads IsraelsenAleksander Krag
Dec 12, 2018·World Journal of Hepatology·Jonathan SolderaAjacio Brandão
Nov 27, 2020·BMC Pharmacology & Toxicology·Günther KrumplJuri Hodisch
Feb 19, 2021·Circulation Journal : Official Journal of the Japanese Circulation Society·Masakazu YamagishiUNKNOWN Japanese Circulation Society Working Group

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiology Journals

Discover the latest cardiology research in this collection of the top cardiology journals.

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.