Docetaxel and hyperthermia: factors that modify thermal enhancement

Journal of Surgical Oncology
Faheez MohamedP H Sugarbaker

Abstract

Hyperthermia enhances the cytotoxicity of some chemotherapeutic agents and recent studies suggest that docetaxel may show improved response at elevated temperatures. Factors that may modify the thermal enhancement of docetaxel were studied to optimize its clinical use with hyperthermia. The tumor studied was an early-generation isotransplant of a spontaneous C3Hf/Sed mouse fibrosarcoma, Fsa-II. All studies were approved by the Animal Care and Use Committee. Docetaxel was given as a single intraperitoneal injection. Hyperthermia was achieved by immersing the tumor-bearing foot into a constant temperature water bath. Four factors were studied: duration of hyperthermia, sequencing of hyperthermia with docetaxel, intensity of hyperthermia, and tumor size. To study duration of hyperthermia tumors were treated at 41.5 degrees C for 30 or 90 min immediately after intraperitoneal administration of docetaxel. For sequencing of hyperthermia and docetaxel, animals received hyperthermia treatment of tumors for 30 min at 41.5 degrees C immediately after drug administration, hyperthermia both immediately and 3 hr after docetaxel administration and hyperthermia given only at 3 hr after administration of docetaxel. Intensity of hyperthermia wa...Continue Reading

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Citations

Nov 22, 2011·Journal of Gastroenterology and Hepatology·Motohira YoshidaYuji Watanabe
Nov 9, 2007·PloS One·Bassim Al-SakereLluis M Mir
Oct 2, 2012·Surgical Oncology Clinics of North America·Kurt Van der SpeetenPaul H Sugarbaker
Mar 25, 2008·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Baorui LiuXiqun Jiang
Aug 28, 2009·International Journal of Cancer. Journal International Du Cancer·Motohira YoshidaKanji Kawachi
Apr 19, 2006·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·E de BreeD D Tsiftsis
Jul 11, 2012·Gastroenterology Research and Practice·K Van der SpeetenP H Sugarbaker
Aug 19, 2007·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·P H Sugarbaker

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