Docetaxel-based induction therapy prior to radiotherapy with or without docetaxel for non-small-cell lung cancer.

British Journal of Cancer
G V ScagliottiC Manegold

Abstract

This trial aimed to assess the feasibility and tumour control of concurrent chemoradiotherapy or radiotherapy alone after docetaxel-based induction chemotherapy in locally advanced non-small-cell lung cancer (NSCLC). Patients with stage IIIA/IIIB NSCLC received two 21-day cycles of induction chemotherapy with docetaxel (85 mg m(-2), day 1) plus cisplatin (40 mg m(-2), days 1 and 2). Patients without disease progression on day 43 were randomised to radiotherapy (2 Gy for 5 days week(-1); total 60 Gy) alone or with docetaxel 20 mg m(-2) once weekly every 6 weeks. Of 108 patients who received induction chemotherapy, 104 were evaluable for response. After induction chemotherapy, the overall response rate (ORR) was 44%; 91 (88%) patients had no disease progression and 89 were subsequently randomised to local treatment. After randomised therapy, the ORR was 53% (chemoradiotherapy 58%; radiotherapy 48%). Median survival and time to progression were 14.9 and 7.8 months, respectively, for chemoradiotherapy and 14.0 and 7.5 months, respectively, for radiotherapy. The most common toxicities during induction chemotherapy and randomised therapy were grades 3-4 neutropenia and grade 3 lymphocytopenia, respectively. Docetaxel-cisplatin induct...Continue Reading

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Citations

Dec 4, 2009·International Journal of Cancer. Journal International Du Cancer·Hui-Ying LiangBao-Sen Zhou
Jul 25, 2007·Traffic·Silvio O Rizzoli, Reinhard Jahn
Dec 24, 2010·Current Opinion in Oncology·Paul BaasMichel van den Heuvel
Jun 20, 2013·Current Oncology Reports·Farhad FakhrejahaniTarek Mekhail
Jun 18, 2010·The Cochrane Database of Systematic Reviews·Noelle O'RourkeFergus Macbeth

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