Abstract
Concurrent chemoradiotherapy (CRT) is the standard treatment for advanced head and neck squamous cell carcinoma. In this phase II randomized study, the efficacy and toxicity of docetaxel, cisplatin and 5-fluorouracil induction chemotherapy (ICT) followed by concurrent CRT was compared with those after standard CRT alone in patients with locally advanced, unresectable head and neck cancer. Between January 2007 and June 2009, 66 patients with advanced (stage III or IV) unresectable squamous cell carcinoma of the head and neck (oral cavity, oropharynx, hypopharynx, and larynx) were randomly assigned to two groups: one receiving two cycles of docetaxel, cisplatin, and 5-fluorouracil ICT followed by CRT with three cycles of cisplatin and one treated by CRT alone. Response rate, local tumor control (LTC), locoregional tumor control (LRTC), overall survival (OS), progression-free survival (PFS), and toxicity results were assessed. Three patients from the ICT + CRT group did not appear at the first treatment, so a total of 63 patients were evaluated in the study (30 ICT + CRT group and 33 CRT group). Three patients died of febrile neutropenia after ICT. The median follow-up time for surviving patients was 63 months (range 53-82 months)...Continue Reading
References
Feb 3, 2000·Journal of the National Cancer Institute·P TherasseS G Gwyther
Dec 31, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·David J AdelsteinArlene A Forastiere
Dec 3, 2003·The New England Journal of Medicine·Arlene A ForastiereJay Cooper
Apr 30, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·K Kian AngRandal S Weber
Oct 13, 2005·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Ruud WiggenraadHenk Struikmans
Oct 26, 2007·The New England Journal of Medicine·Marshall R PosnerUNKNOWN TAX 324 Study Group
Mar 26, 2009·Journal of the National Cancer Institute·Yoann PointreauGilles Calais
May 19, 2009·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Jean-Pierre PignonUNKNOWN MACH-NC Collaborative Group
Feb 19, 2013·The Lancet Oncology·Robert HaddadMarshall Posner
Apr 2, 2013·Critical Reviews in Oncology/hematology·Athanassios Argiris
Jul 4, 2013·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·J O BrömmeD M Aebersold
Jul 10, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Pierre BlanchardUNKNOWN Meta-Analysis of Chemotherapy in Head and Neck Cancer, Induction Project, Collaborative Group
Nov 22, 2013·Annals of Oncology : Official Journal of the European Society for Medical Oncology·R HittUNKNOWN Spanish Head and Neck Cancer Cooperative Group (TTCC)
Jan 15, 2014·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·P BalermpasC Weiss
Citations
Nov 20, 2015·Cancer Research and Treatment : Official Journal of Korean Cancer Association·Ryul KimDae Seog Heo
Dec 26, 2015·Marine Drugs·Yifan HanBao-Hong Lee
Apr 21, 2016·Future Oncology·Roger Ove, Lisle M Nabell
Nov 22, 2015·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Wilfried BudachChristiane Matuschek
Mar 17, 2017·Head & Neck·William A StokesSana D Karam
Jul 18, 2017·Oncology Reports·Shujing WangCongying Li
Feb 24, 2019·The Oncologist·Bhumsuk KeamDae Seog Heo
May 24, 2017·The Oncologist·Petr SzturzJan B Vermorken
Nov 2, 2017·Oncotarget·Lina FanHongbing Lv
Sep 14, 2017·Acta Oto-laryngologica·Andrew M Vahabzadeh-HaghWilliam C Lorentz
Apr 15, 2017·The Cancer Journal·Liat VidalAron Popovtzer
Dec 10, 2017·Journal of Cancer Research and Clinical Oncology·Natalie M LoweNicholas J Slevin
Feb 18, 2016·Medicine·Jin-Hua ChenSzu-Yuan Wu
Dec 14, 2018·Medicina·Viktoras RudžianskasElona Juozaitytė
Apr 10, 2017·Medical Oncology·D AlterioB A Jereczek-Fossa
Jan 31, 2021·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Benjamin LacasUNKNOWN MACH-NC Collaborative Group
Apr 9, 2021·BMC Cancer·Maureen BernadachJulian Biau
Apr 17, 2021·The Lancet Oncology·Claire PetitUNKNOWN MACH-NC and MARCH Collaborative Groups
May 30, 2019·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·M BernadachJ Biau
Jul 28, 2019·Oral Oncology·Etienne DauzierUNKNOWN MACH-NC Collaborative Group
Apr 29, 2021·Cancer·Ahmed S AbdelmeguidEhab Y Hanna
May 23, 2021·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Felix KeilRichard Greil