Docetaxel gold complex nanoflowers: A chemo-biological evaluation for their use as nanotherapeutics.

Colloids and Surfaces. B, Biointerfaces
Maroua Ben HaddadaJolanda Spadavecchia

Abstract

Docetaxel (DTX) is an anticancer treatment widely used in the clinic for the treatment of various human malignancies, including Non-Small-Cell Lung Cancer (NSCLC). Its low water solubility and systemic toxicity, however, negatively impact the clinical application of such drug. In order to improve DTX solubility in biological fluids and decrease its adverse effects in patients, the scientific community is currently focusing on developing drug delivery systems where DTX is the payload. In this context, the present study aims at presenting a step forward in the development of platforms based on gold complexes for multifunctional approaches (theragnostic tools) and stimuli-responsive therapies. Tetrachloroauric acid (HAuCl4) were complexed with the antitumor drug and dicarboxylic acid-terminated polyethylene-glycol (PEG) to form the nanometric complex named DTX-Au-PEG. Following reduction with sodium borohydride (NaBH4), the DTX-Au-PEG complex formed hybrid-metal nanoparticles (DTX IN PEG-AuNPs), where DTX was protected in the gold core embedded within the polymer chains. To achieve therapeutic targeting, DTX-Au-PEG complex and DTX IN PEG-AuNPs were chemical combined with the human anti-EGFR polyclonal antibody, which recognizes th...Continue Reading

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Citations

Mar 26, 2021·International Journal of Nanomedicine·Memona KhanJolanda Spadavecchia
Jun 22, 2021·Seminars in Cancer Biology·Serenella MediciMaria Antonietta Zoroddu
Jul 27, 2021·Current Opinion in Oncology·Nuria KoteckiAhmad Awada

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